Publications by authors named "Jessica Edge"
Article Synopsis
- Implantation in cattle is crucial for successful pregnancies and involves complex changes in the endometrium's transcriptional landscape.
- Factors affecting implantation include embryo development, assisted reproductive technologies, and environmental conditions, showing different processes compared to other placental mammals.
- Current knowledge gaps exist regarding the mechanisms of implantation and how various stressors influence it, but advancements in 3D modeling and data analysis may enhance our understanding and improve implantation outcomes.
Article Synopsis
- The emergence of embryo implantation in mammals around 148 million years ago marked a significant change in reproductive strategies, but the molecular mechanisms behind this adaptation are still not fully understood.
- Progesterone receptor signaling, crucial for mammal pregnancies, predates mammals but does not account for the diverse implantation methods seen in different species.
- The study identifies 13 key microRNA gene families that originated with placental mammals, suggesting a dynamic miRNA network that responds to pregnancy signals and plays a crucial role in the distinct implantation strategies across various species like bovines and humans.
We tested the hypothesis that conserved placental mammal-specific microRNAs and their targets facilitate endometrial receptivity to implantation. Expression of miR-340-5p, -542-3p, and -671-5p was regulated by exposure of endometrial epithelial cells to progesterone (10 μg/ml) for 24 h coordinate with 1,713 of their predicted targets. Proteomic analysis of cells transfected with miRNA mimic/inhibitor (48 h: n = 3) revealed 1,745 proteins altered by miR-340-5p (mimic; 1,369, inhibitor; 376) of which 171 were predicted targets and P4-regulated.
View Article and Find Full Text PDFBackground & Aims: Some women with urge-predominant fecal incontinence (FI) have diarrhea-predominant irritable bowel syndrome and a stiffer and hypersensitive rectum. We evaluated the effects of the α2-adrenergic agonist clonidine on symptoms and anorectal functions in women with FI in a prospective, placebo-controlled trial.
Methods: We assessed bowel symptoms and anorectal functions (anal pressures, rectal compliance, and sensation) in 43 women (age, 58 ± 2 y) with urge-predominant FI, randomly assigned to groups given oral clonidine (0.
Anal sphincteric neurogenic injury in asymptomatic nulliparous women and fecal incontinence.
Am J Physiol Gastrointest Liver Physiol
July 2012
While anal sphincter neurogenic injury documented by needle electromyography (EMG) has been implicated to cause fecal incontinence (FI), most studies have been uncontrolled. Normal values and the effects of age on anal sphincter motor unit potentials (MUP) are ill defined. The functional significance of anal sphincter neurogenic injury in FI is unclear.
View Article and Find Full Text PDFEffect of nifedipine on anorectal sensorimotor functions in health and fecal incontinence.
Am J Physiol Gastrointest Liver Physiol
July 2011
The mechanisms of increased rectal stiffness in women with fecal incontinence (FI) and rectal urgency are not understood. Our hypothesis was that distention-induced activation of mechanosensitive L-type calcium channels in smooth muscle contributes to increased rectal stiffness in FI. Anal pressures, rectal distensibility (compliance, capacity, and contractile response to sinusoidal oscillation), and rectal sensation were assessed before and after oral nifedipine (30 + 10 mg) or placebo in 16 women with FI and 16 asymptomatic women.
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