Publications by authors named "Jessica DeHart"
Background: A high body mass index (BMI, kg/m) is associated with decreased risk of breast cancer before menopause, but increased risk after menopause. Exactly when this reversal occurs in relation to menopause is unclear. Locating that change point could provide insight into the role of adiposity in breast cancer etiology.
View Article and Find Full Text PDFPurpose: Less invasive decision support tools are desperately needed to identify occult high-risk disease in men with prostate cancer (PCa) on active surveillance (AS). For a variety of reasons, many men on AS with low- or intermediate-risk disease forgo the necessary repeat surveillance biopsies needed to identify potentially higher-risk PCa. Here, we describe the development of a blood-based immunocyte transcriptomic signature to identify men harboring occult aggressive PCa.
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- The study analyzed data from over 1 million women across various regions to explore the relationship between reproductive and hormonal factors and the risk of differentiated thyroid cancer (DTC).
- Findings indicated that certain factors, such as younger age at menarche and menopause, use of hormone therapy, and previous surgeries like hysterectomy, were associated with an increased risk of DTC, while long-term oral contraceptive use and being post-menopausal were linked to a lower risk.
- The researchers caution that the associations identified are relatively weak and recommend further studies to clarify the effects of sex steroid hormones on DTC risk.
Background: The link between Epstein-Barr Virus (EBV) and breast cancer (BC) etiology remains unclear. We utilized the Health of Women (HOW) Study to understand the association between infectious mononucleosis (IM), a surrogate for EBV infection, and invasive BC.
Methods: The HOW Study was a web-based survey of BC risk factors with > 40, 000 participants; 183 had IM at < 10 years old, 3, 654 had IM between 10 and 22 years old, 764 had IM at > 22 years old, and 17, 026 never developed IM.
Purpose: In 2014, data from a comprehensive multiplatform analysis of 496 adult papillary thyroid cancer samples reported by The Cancer Genome Atlas project suggested that reclassification of thyroid cancer into molecular subtypes, -like and -like, better reflects clinical behavior than sole reliance on pathologic classification. The aim of this study was to categorize the common oncogenic variants in pediatric differentiated thyroid cancer (DTC) and investigate whether mutation subtype classification correlated with the risk of metastasis and response to initial therapy in pediatric DTC.
Methods: Somatic cancer gene panel analysis was completed on DTC from 131 pediatric patients.
Article Synopsis
- - The study examined the link between low-grade inflammation and health issues in 822 women participating in the California Teachers Study, focusing on factors like body mass index (BMI), diabetes, and physical activity levels.
- - Obese women showed higher levels of several immune biomarkers compared to those with normal BMI, while higher physical activity levels were linked to lower levels of these biomarkers, suggesting a protective effect.
- - The research found significant associations between diabetes and inflammatory markers, indicating that certain immune pathways related to inflammation were influenced by both obesity and physical activity patterns.
Introduction: There is an unmet need for noninvasive methods to better identify patients at increased risk for clinically significant prostate cancer. SelectMDx® is a molecular urine test validated for the detection of Gleason score 7 and higher cancers (ISUP [International Society of Urological Pathology] Grade Group 2-5). In this multicenter trial we evaluated the test's impact on prostate biopsy decision making in clinical practice.
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