Publications by authors named "Jessica D Goncalves"
Leprosy is a chronic infectious disease caused by the intracellular bacillus Mycobacterium leprae (M. leprae), which is known to infect skin macrophages and Schwann cells. Although adipose tissue is a recognized site of Mycobacterium tuberculosis infection, its role in the histopathology of leprosy was, until now, unknown.
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- * Researchers created a model of malignant astrocyte transformation by repeatedly exposing healthy primary astrocytes to conditions that prevented adhesion, leading to cells exhibiting cancer-like behaviors.
- * Molecular analysis showed that transformed cells had changes in gene expression linked to key signaling pathways and behaviors associated with tumor progression, indicating this model could aid in developing treatments and understanding astrocytoma development.
Article Synopsis
- Melanoma is a highly aggressive skin cancer linked to high mortality rates, partly due to its ability to spread (metastasize) and elevated reactive oxygen species (ROS) levels, like superoxide anion.
- Nitric oxide synthase (NOS) can become dysfunctional (uncoupled), producing more ROS when there's a lack of its cofactor tetrahydrobiopterin (BH4), which is crucial for its proper function.
- Treating melanoma cells with BH4 restores NOS function, increasing nitric oxide production, reducing harmful ROS, and ultimately leading to decreased cell growth, reduced ability to form tumors, and increased sensitivity to programmed cell death (apoptosis).
Article Synopsis
- * The study aimed to identify genes related to cell differentiation and proliferation that are differently expressed in ccRCC, using techniques like quantitative PCR (qPCR) and immunohistochemistry.
- * Key findings include the underexpression of genes occludin (OCLN) and growth arrest-specific 1 (GAS1), which may be regulated by specific microRNAs, and the significant overexpression of solute carrier family 2 member 1 (SLC2A1) in ccRCC samples.