Respiratory muscle work influences locomotor convective and diffusive oxygen transport in human heart failure during exercise.

Introduction: It remains unclear if naturally occurring respiratory muscle (RM) work influences leg diffusive O transport during exercise in heart failure patients with reduced ejection fraction (HFrEF). In this retrospective study, we hypothesized that RM unloading during submaximal exercise will lead to increases in locomotor muscle O diffusion capacity (D O ) contributing to the greater leg VO .

Methods: Ten HFrEF patients and 10 healthy control matched participants performed two submaximal exercise bouts (i.

Combined influence of inspiratory loading and locomotor subsystolic cuff inflation on cardiovascular responses during submaximal exercise.

It is unknown if simultaneous stimulation of the respiratory and locomotor muscle afferents via inspiratory loading (IL) and locomotor subsystolic cuff inflation (CUFF) influences the cardiovascular responses during exercise. We hypothesized that combined IL and CUFF (IL + CUFF) will result in greater increases in blood pressure (MAP) and systemic vascular resistance (SVR) than IL and CUFF alone during exercise. Eight adults (6 males/2 females) were enrolled and performed four 10-min bouts of constant-load cycling eliciting 40% maximal oxygen uptake on a single day.

Predictors of exercise capacity following septal myectomy in patients with hypertrophic cardiomyopathy.

Aims: Patients with hypertrophic obstructive cardiomyopathy (HOCM) have impaired exercise capacity. The gold standard therapy for patients with HOCM is septal myectomy surgery; however, changes in maximum oxygen uptake (VOpeak) following myectomy are variable, with VOpeak decreasing in some patients. Therefore, we evaluated changes in VOpeak following surgical myectomy to determine clinical predictors of those exhibiting decreased VOpeak post-myectomy.

Influence of Sex, Menstrual Cycle, and Menopause Status on the Exercise Pressor Reflex.

In this review, we highlight the underlying mechanisms responsible for the sex differences in the exercise pressor reflex (EPR), and, importantly, the impact of sex hormones and menopausal status. The EPR is attenuated in premenopausal women compared with age-matched men. Specifically, activation of the metaboreflex (a component of the EPR) results in attenuated increases in blood pressure and sympathetic vasomotor outflow compared with age-matched men.