Publications by authors named "Jessica D'Angelo"
Acceptability and tolerability of long-acting injectable cabotegravir or rilpivirine in the first cohort of virologically suppressed adolescents living with HIV (IMPAACT 2017/MOCHA): a secondary analysis of a phase 1/2, multicentre, open-label, non-comparative dose-finding study.
Elizabeth D Lowenthal Jennifer Chapman Rachel Ohrenschall Katherine Calabrese Kristin Baltrusaitis Jessica D'Angelo
Lancet HIV
April 2024
Article Synopsis
- Long-acting injectable cabotegravir and rilpivirine have proven effective and safe for adults with HIV-1, making their use in adolescents a focus of the MOCHA study, which assessed acceptability and tolerability for participants aged 12-17.
- The study involved 55 adolescents who had stable HIV-1 treatment, measuring pain levels from injections and overall quality of life through surveys and interviews over several weeks.
- Results indicated high acceptability, with 83% of participants reporting minimal pain after the first injection and a significant number showing a positive response to the treatment by week 8.
Satellite RNAs (satRNAs) are a class of small parasitic RNA replicon that associate with different viruses, including plus-strand RNA viruses. Because satRNAs do not encode a polymerase or capsid subunit, they rely on a companion virus to provide these proteins for their RNA replication and packaging. SatRNAs recruit these and other required factors via their RNA sequences and structures.
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