Publications by authors named "Jessica Cristina Araujo-Souza"
Atherosclerosis
March 2017
Article Synopsis
- LPC, a component of oxidized LDL, causes endothelial dysfunction by reducing NO production and increasing vasoconstriction in mouse aorta and human endothelial cells.
- Inhibition of nNOS and degradation of HO lessen the relaxation response and impact the physiological functions controlled by endothelial cells.
- ERK1/2 pathway plays a crucial role, as blocking it alleviates the effects of LPC, indicating potential therapeutic targets for mitigating endothelial dysfunction.
