A Scoping Review Exploring Access to Survivorship Care for Childhood, Adolescent, and Young Adult Cancer Survivors: How Can We Optimize Care Pathways?

Childhood, adolescent, and young adult (CAYA) cancer survivors are at risk of developing late effects associated with their cancer and its treatment. Survivors' engagement with recommended follow-up care to minimize these risks is suboptimal, with many barriers commonly reported. This scoping review aims to summarize the barriers to accessing follow-up care, using the dimensions of Levesque's framework for accessing healthcare.

Long-term exposure of chemokine CXCL10 causes bronchiolitis-like inflammation.

Chemokines and chemokine receptors have been implicated in the pathogenesis of bronchiolitis. CXCR3 ligands (CXCL10, CXCL9, and CXCL11) were elevated in patients with bronchiolitis obliterans syndrome (BOS) and chronic allorejection. Studies also suggested that blockage of CXCR3 or its ligands changed the outcome of T-cell recruitment and airway obliteration.

One-year trajectories of care and resource utilization for recipients of prolonged mechanical ventilation: a cohort study.

Background: Growing numbers of critically ill patients receive prolonged mechanical ventilation. Little is known about the patterns of care as patients transition from acute care hospitals to postacute care facilities or about the associated resource utilization.

Objective: To describe 1-year trajectories of care and resource utilization for patients receiving prolonged mechanical ventilation.

Expectations and outcomes of prolonged mechanical ventilation.

Objective: To compare prolonged mechanical ventilation decision-makers' expectations for long-term patient outcomes with prospectively observed outcomes and to characterize important elements of the surrogate-physician interaction surrounding prolonged mechanical ventilation provision. Prolonged mechanical ventilation provision is increasing markedly despite poor patient outcomes. Misunderstanding prognosis in the prolonged mechanical ventilation decision-making process could provide an explanation for this phenomenon.

Diagnosis and outcome of early pleural space infection following lung transplantation.

Background: Despite the frequent occurrence of pleural effusions in lung transplant recipients, little is known about early posttransplant pleural space infections. We sought to determine the predictors and clinical significance of pleural infection in this population.

Methods: We analyzed 455 consecutive lung transplant recipients and identified patients who had undergone sampling of pleural fluid within 90 days posttransplant.

Effects of respiratory-therapist driven protocols on house-staff knowledge and education of mechanical ventilation.

High practice variability in critical care medicine contributes to medical errors and the high cost of ICU care. Clinical guidelines and protocol-based strategies can reduce the variation and cost of ICU medicine, increase adherence to evidence-based interventions, and reduce error, thereby improving the morbidity and mortality of critically ill patients. There are various barriers to guideline adherence, and protocols often are more successful when implemented by nonphysicians.