Publications by authors named "Jessica Case"
Introduction: AG200-15, an investigational transdermal contraceptive delivery system or patch, is designed to be a low-dose, non-daily, combined hormonal contraceptive option for women. In this phase 1 study, the in vivo adhesion of the AG200-15 patch was compared to Xulane, the only contraceptive patch available in the USA.
Methods: This phase 1, randomized, open-label, single-dose, two-treatment, two-period crossover adhesion study compared the 7-day adhesion of the AG200-15 and Xulane contraceptive patches.
: A radiation-attenuated (Pf) sporozoite (SPZ) malaria vaccine, PfSPZ Vaccine, protected 6 of 6 subjects (100%) against homologous Pf (same strain as in the vaccine) controlled human malaria infection (CHMI) 3 weeks after 5 doses administered intravenously. The next step was to assess protective efficacy against heterologous Pf (different from Pf in the vaccine), after fewer doses, and at 24 weeks. : The trial assessed tolerability, safety, immunogenicity, and protective efficacy of direct venous inoculation (DVI) of 3 or 5 doses of PfSPZ Vaccine in non-immune subjects.
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- The study investigates how common peripheral artery disease (PAD) is among patients who have left ventricular systolic dysfunction, heart failure, or both after an acute myocardial infarction (MI).
- PAD is linked to worse cardiovascular outcomes, highlighting its significance for patients already at high risk post-MI.
- The research found that patients with PAD had a higher mortality risk and poorer overall cardiovascular health, suggesting the need for focused preventive treatments for this vulnerable group.