Publications by authors named "Jessica C Garcia"
Impact of Retinal Degeneration on Response of ON and OFF Cone Bipolar Cells to Electrical Stimulation.
IEEE Trans Neural Syst Rehabil Eng
May 2023
Article Synopsis
- * Current interventions are typically considered in later disease stages, leaving only inner retinal cells, but early-stage treatment may focus on stimulating bipolar cells that receive signals from the deteriorating photoreceptors.
- * Computational models of healthy and degenerated cone bipolar cells showed that healthy ON cells respond faster to stimulation and have lower calcium channel currents compared to degenerated cells, indicating different dynamics in how these cells react to electrical stimulation.
Connectomics has demonstrated that synaptic networks and their topologies are precise and directly correlate with physiology and behavior. The next extension of connectomics is pathoconnectomics: to map neural network synaptology and circuit topologies corrupted by neurological disease in order to identify robust targets for therapeutics. In this report, we characterize a pathoconnectome of early retinal degeneration.
View Article and Find Full Text PDFGlia play important roles in neural function, including but not limited to amino acid recycling, ion homeostasis, glucose metabolism, and waste removal. During retinal degeneration and subsequent retinal remodeling, Müller cells (MCs) are the first cells to show metabolic and morphological alterations in response to stress. Metabolic alterations in MCs chaotically progress in retina undergoing photoreceptor degeneration; however, what relationship these alterations have with neuronal stress, synapse maintenance, or glia-glia interactions is currently unknown.
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