Publications by authors named "Jessica Bentz"
Article Synopsis
- The systematic review aimed to assess how testosterone affects uterine and ovarian health in transmasculine individuals undergoing gender-affirming surgery.
- After analyzing 28 full-text articles, it was found that the majority of endometrial tissues were either atrophic or proliferative, with a few cases showing precancerous changes.
- No ovarian cancers were identified, suggesting that testosterone treatment does not significantly elevate the risk of serious gynecological issues in these patients.
Article Synopsis
- * The study explored connections between different types of hyperglycemia (like gestational diabetes and type 2 diabetes) and specific miRNAs in late pregnancy.
- * Seven particular miRNAs were found to be linked to hyperglycemia and glucose levels, influencing important biological processes related to maternal and child health, such as insulin signaling and placental development.
Nearly all cervical cancers are caused by persistent high-risk human papillomavirus (hrHPV) infection. There are 14 recognized hrHPV genotypes (HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68), and hrHPV genotypes 16 and 18 comprise approximately 66% of all cases worldwide. An additional 15% of cervical cancers are caused by hrHPV genotypes 31, 33, 45, 52, and 58.
View Article and Find Full Text PDFTumors with pathogenic DICER1 mutation are rare and encompass sporadic or hereditary benign, intermediate and malignant tumors. DICER1-associated sarcomas are heterogeneous; however, the prototypical ones in the GYN-tract include embryonal rhabdomyosarcoma, adenosarcoma and moderately to poorly differentiated Sertoli-Leydig tumor. In this report, we present three unique uterine sarcomas with DICER1 mutation and remarkable diffuse round/spindle cell morphology.
View Article and Find Full Text PDFArticle Synopsis
- * The study presents EndoNet, an AI model that uses convolutional neural networks and vision transformers to classify endometrial cancer slides into low-grade and high-grade categories based on histologic features.
- * EndoNet was trained on 929 images and showed strong performance in both internal and external tests, achieving high F1 scores and areas under the curve, suggesting it could help pathologists classify tumors more efficiently without manual input.
Differentiated vulvar intraepithelial neoplasia (d-VIN) is an HPV-independent precursor to vulvar squamous cell carcinoma. The histology of d-VIN lesions is difficult to differentiate from that of non-neoplastic epithelial disorders, especially lichen sclerosus (LS). The authors present a case of LS, where relying on histopathology alone could have led to misdiagnosis.
View Article and Find Full Text PDF•Adverse events of pembrolizumab have been documented, but more severe gastrointestinal effects are not as well described.•We report a case of a patient with cervical cancer treated with pembrolizumab who developed small bowel obstruction (SBO)•Histological analysis and gastrointestinal workup points to pembrolizumab as likely cause of SBO.
View Article and Find Full Text PDFObjective: To evaluate predictors of recurrence and the risk of progression to carcinoma in patients with dVIN.
Methods: 36 self-identified White patients with dVIN from 2011 to 2022 were identified. Demographics, treatment and clinical course were abstracted.