Publications by authors named "Jessica Bateson"
Article Synopsis
- Most lung cancer patients, especially those with EGFR mutations, develop resistance to treatment drugs like osimertinib and gefitinib, often leading to relapse.* -
- Genome-wide CRISPR screenings pinpointed key resistance pathways, revealing that regulation of the Hippo pathway is a significant factor in this drug resistance among cancer cells.* -
- Targeting both the Hippo pathway and EGFR together shows promise as a new treatment approach for EGFR mutant lung cancer, potentially improving outcomes for patients.*
New therapeutic targets for oral squamous cell carcinoma (OSCC) are urgently needed. We conducted genome-wide CRISPR-Cas9 screens in 21 OSCC cell lines, primarily derived from Asians, to identify genetic vulnerabilities that can be explored as therapeutic targets. We identify known and novel fitness genes and demonstrate that many previously identified OSCC-related cancer genes are non-essential and could have limited therapeutic value, while other fitness genes warrant further investigation for their potential as therapeutic targets.
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