Kidney toxicogenomics of chronic potassium bromate exposure in f344 male rats.

Background: Potassium bromate (KBrO3), used in both the food and cosmetics industry, and a drinking water disinfection by-product, is a nephrotoxic compound and rodent carcinogen. To gain insight into the carcinogenic mechanism of action and provide possible biomarkers of KBrO3 exposure, the gene expression in kidneys from chronically exposed male F344 rats was investigated.

Methods: Male F344 rats were exposed to KBrO3 in drinking water for 52 and 100 wk.