Publications by authors named "Jessica A Livesey"
Article Synopsis
- Striatal adenosine A receptors (ARs) can inhibit dopamine release, with their activity being regulated by astrocytic equilibrative nucleoside transporter 1 (ENT1), which is sensitive to ethanol.
- In experiments with striatal slices from mice, activating ARs diminished dopamine release, especially at lower stimulation rates, while blocking ARs heightened dopamine release levels, indicating a fundamental tonic inhibition.
- The study found that inhibiting ENT1 increased adenosine levels, further enhancing AR-mediated inhibition, while ethanol reduced adenosine uptake through ENT1, thus promoting dopamine output dynamics and highlighting the complex role of astrocytes in regulating striatal function under the influence of ethanol.
