Publications by authors named "Jesse T Edmond"
Article Synopsis
- * This large-scale study analyzed MRI scans from over 2,000 schizophrenia patients and 2,800 healthy controls to assess brain volume and microstructural integrity, using advanced modeling techniques.
- * Results showed that aggressive behavior was significantly associated with reduced cortical and white matter volumes, particularly in key brain areas, suggesting a direct neurological link to aggression in schizophrenia patients.
Article Synopsis
- The study looked at how the brain's left and right sides might differ in people with schizophrenia compared to those without it, using brain scans from over 5,000 patients and 6,000 control subjects.
- Researchers found that people with schizophrenia had slightly thinner areas in the left side of their brains, especially in certain regions, compared to those without the disorder.
- The differences in brain structure might be linked to how schizophrenia affects brain functions, like language, but more research is needed to understand why they happen.
This study examined associations between resting-state amplitude of low frequency fluctuations (ALFF) and negative symptoms represented by total scores, second-order dimension (motivation and pleasure, expressivity), and first-order domain (anhedonia, avolition, asociality, alogia, blunted affect) factor scores in schizophrenia (n = 57). Total negative symptom scores showed positive associations with ALFF in temporal and frontal brain regions. Negative symptom domain scores showed predominantly stronger associations with regional ALFF compared to total scores, suggesting domain scores may better map to neural signatures than total scores.
View Article and Find Full Text PDFBackground: Structural neuroimaging studies have identified similarities in the brains of individuals diagnosed with schizophrenia (SZ) and bipolar I disorder (BP), with overlap in regions of gray matter (GM) deficits between the two disorders. Recent studies have also shown that the symptom phenotypes associated with SZ and BP may allow for a more precise categorization than the current diagnostic criteria. In this study, we sought to identify GM alterations that were unique to each disorder and whether those alterations were also related to unique symptom profiles.
View Article and Find Full Text PDF