Sodium Alkyl(trimethylsilyl)amides: Substituent- and Solvent-dependent Solution Structures and Reactivities.

The preparation of sodium isopropyl(trimethylsilyl)amide (NaPTA), sodium (1-phenylethyl)(trimethylsilyl)amide (NaPETA), sodium -butyl(trimethylsilyl)amide (NaBTA), and isotopologues [N]NaPTA and [N]NaBTA are described. Solution structural studies using a combination of Si NMR spectroscopy, the Method of Continuous Variations, and density functional theory computations provided insights into aggregation and solvation in a range of solvents including toluene, ,-dimethylethylamine, triethylamine, MTBE, THF, 1,2-dimethoxyethane (DME), diglyme, ,,','-tetramethylethylenediamine (TMEDA), ,,','-tetramethylcyclohexanediamine (TMCDA), ,,',″,″-pentamethyldiethylenetriamine (PMDTA). 12-crown-4, 15-crown-5, and 18-crown-6 revealed solvent- and substituent-dependent dimer-monomer mixtures with affiliated solvation numbers.

Potassium Hexamethyldisilazide (KHMDS): Solvent-Dependent Solution Structures.

Solution structures of potassium hexamethyldisilazide [KHMDS] and labeled [N]KHMDS were examined using a number of analytical methods including Si NMR spectroscopy and density functional theory computations. A combination of N-Si couplings, Si chemical shifts, and the method of continuous variations reveals dimers, monomers, and ion pairs. Weakly coordinating monofunctional ligands such as toluene, -dimethylethylamine, and EtN afford exclusively dimers.

Carboxylate-Capped Analogues of Ru265 Are MCU Inhibitor Prodrugs.

The mitochondrial calcium uniporter (MCU) is a transmembrane protein that resides on the inner membrane of the mitochondria and mediates calcium uptake into this organelle. Given the critical role of mitochondrial calcium trafficking in cellular function, inhibitors of this channel have arisen as tools for studying the biological relevance of this process and as potential therapeutic agents. In this study, four new analogues of the previously reported Ru-based MCU inhibitor [ClRu(NH)(μ-N)Ru(NH)Cl]Cl (Ru265) are reported.