Nonapoptotic role of EGL-1 in exopher production and neuronal health in .

While traditionally studied for their proapoptotic functions in activating the caspase, research suggests BH3-only proteins also have other roles such as mitochondrial dynamics regulation. Here, we find that EGL-1, the BH3-only protein in , promotes the cell-autonomous production of exophers in adult neurons. Exophers are large, micron-scale vesicles that are ejected from the cell and contain cellular components such as mitochondria.

Physician preferences of biomarker testing strategies in newly diagnosed stage IV non-small cell lung cancer patients.

To understand physicians' attitudes and behaviors regarding EGFR testing and retesting strategies in newly diagnosed metastatic non-small cell lung cancer patients. Oncologists and pathologists completed an online, cross-sectional survey. Most oncologists (73.

Long-term activity drives dendritic branch elaboration of a C. elegans sensory neuron.

Neuronal activity often leads to alterations in gene expression and cellular architecture. The nematode Caenorhabditis elegans, owing to its compact translucent nervous system, is a powerful system in which to study conserved aspects of the development and plasticity of neuronal morphology. Here we focus on one pair of sensory neurons, termed URX, which the worm uses to sense and avoid high levels of environmental oxygen.

Activity-Dependent Regulation of the Proapoptotic BH3-Only Gene in a Living Neuron Pair in .

The BH3-only family of proteins is key for initiating apoptosis in a variety of contexts, and may also contribute to non-apoptotic cellular processes. Historically, the nematode has provided a powerful system for studying and identifying conserved regulators of BH3-only proteins. In , the BH3-only protein is expressed during development to cell-autonomously trigger most developmental cell deaths.

Roles of ON cone bipolar cell subtypes in temporal coding in the mouse retina.

In the visual system, diverse image processing starts with bipolar cells, which are the second-order neurons of the retina. Thirteen subtypes of bipolar cells have been identified, which are thought to encode different features of image signaling and to initiate distinct signal-processing streams. Although morphologically identified, the functional roles of each bipolar cell subtype in visual signal encoding are not fully understood.