Publications by authors named "Jessa R Alexander"
Article Synopsis
- The study analyzes the impact of various multiple sclerosis (MS) disease-modifying therapies (DMTs) on the immune response elicited by SARS-CoV-2 vaccination, comparing responses between healthy individuals and MS patients treated with different DMTs.
- Findings indicate that while some DMTs (GA, DMF, NTZ) showed similar anti-spike antibody levels to healthy controls, treatments with anti-CD20 mAbs and S1P receptor modulators resulted in reduced antibody responses and compromised B cell activity.
- T cell reactivity remained mostly robust across groups, although S1P-treated patients displayed weaker CD4+ T cell responses post-vaccination, emphasizing the need for tailored COVID-19 clinical guidelines based on
Importance: Neuropsychiatric manifestations of COVID-19 have been reported in the pediatric population.
Objective: To determine whether anti-SARS-CoV-2 and autoreactive antibodies are present in the cerebrospinal fluid (CSF) of pediatric patients with COVID-19 and subacute neuropsychiatric dysfunction.
Design, Setting, And Participants: This case series includes 3 patients with recent SARS-CoV-2 infection as confirmed by reverse transcriptase-polymerase chain reaction or IgG serology with recent exposure history who were hospitalized at the University of California, San Francisco Benioff Children's Hospital and for whom a neurology consultation was requested over a 5-month period in 2020.
Individuals with coronavirus disease 2019 (COVID-19) frequently develop neurological symptoms, but the biological underpinnings of these phenomena are unknown. Through single-cell RNA sequencing (scRNA-seq) and cytokine analyses of cerebrospinal fluid (CSF) and blood from individuals with COVID-19 with neurological symptoms, we find compartmentalized, CNS-specific T cell activation and B cell responses. All affected individuals had CSF anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies whose target epitopes diverged from serum antibodies.
View Article and Find Full Text PDF