Publications by authors named "Jess T Leonard"
Background: Ribose-5-phosphate isomerase is an enzyme that catalyzes the interconversion of ribose-5-phosphate and ribulose-5-phosphate. This family of enzymes naturally occurs in two distinct classes, RpiA and RpiB, which play an important role in the pentose phosphate pathway and nucleotide and co-factor biogenesis.
Results: Although RpiB occurs predominantly in bacteria, here we report crystal structures of a putative RpiB from the pathogenic fungus Coccidioides immitis.
Article Synopsis
- The Seattle Structural Genomics Center for Infectious Disease is enhancing drug design by integrating ligand-bound structural data into their research pipeline.
- The study focuses on MECP synthase from Burkholderia pseudomallei, using fragment-based screening to identify small molecules that bind to this crucial enzyme.
- Findings reveal new binding pockets and interactions, providing valuable insights for developing new inhibitors and guiding medicinal chemistry efforts.