Publications by authors named "Jess L Algar"
Article Synopsis
- Drug checking helps individuals verify the identity and purity of drugs before use, and the CanTEST Health and Drug Checking Service is the first established service in Australia for this purpose.
- Recently, three samples submitted to the service were expected to be known substances but turned out to be unidentified; further laboratory analysis ultimately revealed them to be new psychoactive substances not previously documented.
- This case highlights the importance of drug checking as a tool for monitoring the unregulated drug market and ensuring safer consumption practices among users.
Article Synopsis
- The study discusses flexible Pd(L) complexes that self-recognize through π-π interactions, which makes it difficult for them to associate with aromatic targets in solution.
- The complex can reversibly transform into an 'open' macrocycle by introducing additional metal ions, thanks to bidentate binding sites in the ligand that include 2-pyridyl-1,2,3-triazole and bis-1,2,3-triazole.
- This controlled process allows for switching between two distinct species, enhancing the interaction of the macrocycle with molecular substrates and regulating guest binding.
Roles of Metal Ions in Foldamers and Other Conformationally Flexible Supramolecular Systems.
ACS Org Inorg Au
December 2022
Conformational control is a key prerequisite for much molecular function. As chemists seek to create complex molecules that have applications beyond the academic laboratory, correct spatial positioning is critical. This is particularly true of flexible systems.
View Article and Find Full Text PDFIn chemistry, function and behaviour flow directly from structure. As chemists seek to develop highly complex functional molecules, we need to harness routes to complex structures. In metallosupramolecular self-assembly, this requires the development of strategies to overcome the tendency of self-assembled systems to be either (1) highly symmetric in the presence of a single ligand type, or (2) statistical equilibrium mixtures in the presence of multiple ligands.
View Article and Find Full Text PDFArticle Synopsis
- Self-assembly of metallo-interlocked architectures is appealing, but they can be diluted due to the presence of smaller species in equilibrium.
- The study introduces a junctioned system that consistently forms a trefoil-entangled tetrahedron, regardless of the concentrations used.
- Heating the sample allows for a reversible shift from the entangled structure to a non-interlocked dual metallo-cycle, indicating that thermal changes can be used to switch structures even without concentrating the components.