Publications by authors named "Jesper Hastrup-Svendsen"
Article Synopsis
- Hidradenitis suppurativa (HS) is linked to a higher risk of cardiovascular diseases, but its genetic connection to cardiometabolic diseases is unclear.
- This study, involving over 391,000 participants from the UK Biobank, analyzed the relationship between a polygenic risk score (PRS) for HS and the likelihood of developing coronary artery disease (CAD) and diabetes.
- Results showed that a high PRS for HS was associated with increased odds of CAD (1.09) and diabetes (1.13), indicating a significant genetic correlation between HS and these cardiometabolic outcomes.
Aims: Wearable health technologies are increasingly popular. Yet, wearable monitoring only works when devices are worn as intended, and adherence reporting lacks standardization. In this study, we aimed to explore the long-term adherence to a wrist-worn activity tracker in the prospective SafeHeart study and identify patient characteristics associated with adherence.
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- - This study investigates the relationship between physical activity and the need for implantable cardioverter defibrillator (ICD) therapy in patients with an ICD by analyzing their movement and sleep data collected via wrist accelerometers over 28 days.
- - Among 253 participants, higher inactive durations and specific walking cadences were linked to an increased risk of needing ICD therapy, with a U-shaped relationship observed for inactivity and a linear relationship for cadence and sleep duration.
- - The findings suggest that monitoring daily movement and sleep patterns could help predict the risk of ventricular arrhythmia, highlighting the need for larger studies to further explore the use of these digital biomarkers in clinical risk assessment.
We aimed to identify and characterise behavioural profiles in patients at high risk of SCD, by using deep representation learning of day-to-day behavioural recordings. We present a pipeline that employed unsupervised clustering on low-dimensional representations of behavioural time-series data learned by a convolutional residual variational neural network (ResNet-VAE). Data from the prospective, observational SafeHeart study conducted at two large tertiary university centers in the Netherlands and Denmark were used.
View Article and Find Full Text PDFPurpose: Subclinical thyroid dysfunction is a marker for atrial fibrillation (AF) and stroke risk. This study explored the effects of AF screening according to thyroid-stimulating hormone (TSH) levels.
Methods: An AF screening trial (the LOOP study) was analyzed post-hoc according to baseline TSH.
Article Synopsis
- The study aims to investigate the genetic factors associated with accessory atrioventricular pathways (APs) and related heart rhythm disorders using a genome-wide association study (GWAS).
- It involved analyzing genetic data from over 1,200,000 control individuals and 2,310 individuals with APs from multiple countries and various health databases.
- Key findings revealed three significant genetic variants linked to APs, particularly in specific genes (CCDC141 and SCN10A), with implications for understanding conditions like paroxysmal supraventricular tachycardia (PSVT).
Article Synopsis
- Advances in ICD treatment highlight the necessity for better candidate selection and risk factor identification due to improved outcomes for patients receiving these devices.
- A study analyzed 2998 ICD patients (avg. age 61.8 years, 20% female) over a median follow-up of 4.3 years, finding that 14.2% experienced shocks, with 12.1% deemed appropriate and 2.7% inappropriate.
- Results suggested that female patients had a lower risk of experiencing appropriate shocks, but only a few clinical factors were useful in predicting shocks, indicating a need for more sophisticated tools for candidate selection in ICD therapy.
Article Synopsis
- A budget impact analysis was conducted to compare the costs of current treatment strategies with a new approach for population screening of atrial fibrillation (AF) in 75-year-olds across eight European countries.
- The analysis showed that while AF screening leads to increased initial costs due to higher drug and screening expenses, it ultimately results in savings from reduced stroke-related costs.
- The net budget impact of implementing AF screening varied by country, ranging from €10 in Ireland to €122 in the Netherlands, demonstrating the overall financial benefit of the screening despite the upfront costs.
Background: Mounting evidence indicates that even device-detected subclinical atrial fibrillation is associated with a higher risk of heart failure (HF). However, the potential impact of atrial fibrillation screening on HF remains unknown.
Methods: The LOOP Study (Atrial Fibrillation detected by Continuous ECG Monitoring using Implantable Loop Recorder to prevent Stroke in High-risk Individuals) evaluated the effects of atrial fibrillation screening on stroke prevention using an implantable loop recorder (ILR) versus usual care in older individuals with additional stroke risk factors.
Background: The treatment of pulmonary hypertension (PH) has improved rapidly in recent decades. There is increasing evidence to support the role of early intervention and treatment in affecting clinical outcomes in PH.
Objectives: To assess treatment effects before and after the escalation of specific PH treatments using continuous heart monitoring with a Reveal LINQ loop recorder.
Background: Lyme borreliosis is a tick-borne disease caused by the bacterium Borrelia burgdorferi (Bb) sensu lato complex. Previous studies have suggested an association between Lyme borreliosis and heart failure, which have been suggested to be a possible manifestation of Lyme carditis. We aimed to investigate the risk of heart failure among individuals tested for serum Bb antibodies, and serum Bb seropositive individuals.
View Article and Find Full Text PDFBackground: Left atrial (LA) speckle tracking provides detailed information on atrial function. Its utility for predicting subclinical atrial fibrillation (SCAF) is unclear. Therefore, we sought to investigate whether LA strain measures could predict SCAF detected by long-term continuous rhythm monitoring.
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- * The LOOP study involved 6,004 AF-naïve individuals aged 70-90 with stroke risk factors, comparing outcomes of those monitored with an implantable loop recorder to usual care, finding that a higher ABC-stroke score significantly indicated increased stroke risk.
- * However, results showed that the ABC-stroke score did not effectively identify which individuals would benefit from AF screening or preventive treatment, suggesting the need for further investigation into its clinical utility.
Objectives: To investigate the short- and long-term risks of atrioventricular block and other cardiac conduction disorders associated with being tested for Borrelia burgdorferi (Bb) antibodies or Bb seropositivity as measures of confounding by indication and Bb infection, respectively.
Methods: We performed a nationwide population-based matched cohort study (Denmark, 1993-2021). We included 52 200 Bb-seropositive individuals (stratified as only Bb-IgM-seropositive [n = 26 103], only Bb-IgG-seropositive [n = 18 698], and Bb-IgM-and-IgG-seropositive [n = 7399]) and two age- and sex-matched comparison cohorts: 104 400 Bb-seronegative individuals and 261 000 population controls.
Epicardial adipose tissue (EAT) has endocrine and paracrine functions and has been associated with metabolic and cardiovascular disease. This study aimed to investigate the association between EAT, determined by cardiac magnetic resonance imaging (CMR), and incident atrial fibrillation (AF) following long-term continuous heart rhythm monitoring by implantable loop recorder (ILR). This study is a sub-study of the LOOP study.
View Article and Find Full Text PDFAtrial fibrillation (AF) prevalence is rising; however, data on the bleeding risks associated with the detection of subclinical AF are needed. Our objective was to determine the bleeding increment associated with implantable loop recorder (ILR) screening for subclinical AF and subsequent anticoagulation initiation compared with usual care. This post hoc study utilized LOOP trial data from 6,004 elderly patients with stroke risks randomized to either ILR ( = 1,503) or usual care ( = 4,503).
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- The study aimed to determine the relationship between changes in QRS duration (∆QRS) after cardiac resynchronization therapy (CRT) and mortality rates among patients with heart failure from the DANISH study.
- Researchers analyzed data from 572 patients and found that while there was a slight reduction in all-cause mortality associated with shorter QRS durations, this association vanished after adjusting for other factors.
- The conclusion indicated that in patients with non-ischemic cardiomyopathy, a reduction in QRS duration after CRT did not correlate with improved long-term survival.
Aims: Pressure-strain loop (PSL) analysis is a novel echocardiographic tool capable of assessing myocardial work non-invasively. In this study, we aim to evaluate the prognostic value of myocardial work indices in the general population.
Methods And Results: This was a prospective community-based cohort study (n = 4466).
Introduction: Patients receiving haemodialysis are at increased risk of arrhythmias and sudden cardiac death, but data on arrhythmia burden and the pathophysiology remain limited. Among potential risk factors, hypoglycaemia is proposed as a possible trigger of lethal arrhythmias. The development of implantable loop recorders (ILR) and continuous glucose monitoring (CGM) enables long-term continuous ECG and glycaemic monitoring.
View Article and Find Full Text PDFMorphology-voltage-P-wave-duration (MVP) score combining P-wave duration (PWD), P-wave voltage in lead I (PWVI), and interatrial block (IAB) has been demonstrated to predict atrial fibrillation (AF). Therefore, this study aimed to examine MVP score and its P-wave components as potential predictors of AF screening effects on stroke prevention. This was a secondary analysis of the LOOP Study (Atrial Fibrillation detected by Continuous ECG Monitoring using Implantable Loop Recorder to prevent Stroke in High-risk Individuals) which randomized older persons (aged 70 to 90 years) with additional stroke risk factors to either continuous monitoring with implantable loop recorder and anticoagulation upon detection of AF episodes ≥6 minutes (the intervention group), or usual care.
View Article and Find Full Text PDFThe relationship between natriuretic peptides and atrial distension is not fully understood. We sought to examine their interrelationship and how they relate to atrial fibrillation (AF) recurrence following catheter ablation. We analyzed patients enrolled in the AMIO-CAT trial (amiodarone vs.
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