Publications by authors named "Jesper Barner Lekdorf"
Article Synopsis
- The study aims to understand the real-world incidence of hypoglycaemia in diabetes patients, using data from the Hypoglycaemia Assessment Tool (HAT) which included 27,585 individuals across 24 countries.
- A literature search identified and compared 24 similar population-based studies, showing varied rates of hypoglycaemia among type 1 diabetes (T1D) and type 2 diabetes (T2D) patients.
- Results indicated a notably higher incidence of hypoglycaemia in T1D patients compared to T2D patients, emphasizing the need for continued education and better treatments to manage these episodes.
Aims/hypothesis: The Trial Comparing Cardiovascular Safety of Insulin Degludec vs Insulin Glargine in Patients with Type 2 Diabetes at High Risk of Cardiovascular Events (DEVOTE) was a double-blind, randomised, event-driven, treat-to-target prospective trial comparing the cardiovascular safety of insulin degludec with that of insulin glargine U100 (100 units/ml) in patients with type 2 diabetes at high risk of cardiovascular events. This paper reports a secondary analysis investigating associations of day-to-day fasting glycaemic variability (pre-breakfast self-measured blood glucose [SMBG]) with severe hypoglycaemia and cardiovascular outcomes.
Methods: In DEVOTE, patients with type 2 diabetes were randomised to receive insulin degludec or insulin glargine U100 once daily.
Aims/hypothesis: The double-blind Trial Comparing Cardiovascular Safety of Insulin Degludec vs Insulin Glargine in Patients with Type 2 Diabetes at High Risk of Cardiovascular Events (DEVOTE) assessed the cardiovascular safety of insulin degludec. The incidence and rates of adjudicated severe hypoglycaemia, and all-cause mortality were also determined. This paper reports a secondary analysis investigating associations of severe hypoglycaemia with cardiovascular outcomes and mortality.
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