Publications by authors named "Jesmine T M Cheung"
Article Synopsis
- Erythropoietin (EPO) signaling is crucial for the final stages of red blood cell development, but how it affects iron metabolism remains unclear.
- Research identified a protein called FAM210B that plays a key role in processes like hemoglobin formation and cell division during this maturation stage.
- FAM210B is not directly an iron transporter but helps in iron import to mitochondria, which is necessary for producing heme and iron-sulfur clusters essential for red blood cell function.
Mitochondrial fission is mediated by the dynamin-related protein Drp1 in metazoans. Drp1 is recruited from the cytosol to mitochondria by the mitochondrial outer membrane protein Mff. A second mitochondrial outer membrane protein, named Fis1, was previously proposed as recruitment factor, but Fis1(-/-) cells have mild or no mitochondrial fission defects.
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