Publications by authors named "Jeshmi Jeyabalan-Srikaran"
Article Synopsis
- - Bardet-Biedl syndrome (BBS) is a ciliopathy that disrupts primary cilia, impacting various organs like the kidneys and eyes, and is influenced by genetic factors and inter-individual variations.
- - The study focuses on the BBS1 protein within the BBSome complex, using genetically modified renal cell lines to explore how mutations affect cell identity and function, revealing clonal variability.
- - Findings indicate that BBS1 is crucial for maintaining epithelial characteristics in cells, with dysregulation in related gene expressions (like those governing epithelial-to-mesenchymal transition) indicating a common issue across different tissues affected by BBS.
Biological complexity is achieved through elaborate interactions between relatively few individual components. Affinity purification (AP) has allowed these networks of protein-protein interactions that regulate key biological processes to be interrogated systematically. In order to perform these studies at the required scale, easily transfectable immortalized cell lines have typically been used.
View Article and Find Full Text PDFNeural crest stem/progenitor cells (NCSCs) populate a variety of tissues, and their dysregulation is implicated in several human diseases including craniosynostosis and neuroblastoma. We hypothesised that small molecules that inhibit NCSC induction or differentiation may represent potential therapeutically relevant drugs in these disorders. We screened 640 FDA-approved compounds currently in clinical use for other conditions to identify those which disrupt development of NCSC-derived skeletal elements that form the zebrafish jaw.
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