Publications by authors named "Jeseung Ryu"
Article Synopsis
- mTOR signaling, specifically through mTORC1 and mTORC2 complexes, is essential for neural development and is linked to various brain disorders, but upstream regulators of this signaling in neurons are not fully understood.
- This study highlights Tanc2, a neurodevelopmental adaptor protein, as a direct inhibitor of mTOR, with experiments showing that mice lacking Tanc2 exhibit severe developmental issues, while those with reduced Tanc2 levels show mTOR hyperactivity and related behavioral problems that can be reversed with the drug rapamycin.
- Tanc2 specifically inhibits mTOR in different stages of neuron development and in human neural progenitor cells, suggesting its significant role in regulating mTOR activity during neurodevelopment.
