Lipophilicity study of some non-steroidal anti-inflammatory agents and cephalosporin antibiotics: a review.

Lipophilicity properties have long been considered a vital component of drug discovery and development, providing insight into the role of molecular properties in the biological activity of known and new compounds. An extensive survey of the literature published in analytical and pharmaceutical chemistry journals has been conducted. Separation, optical, electrochemical and calculation methods which were developed and used for determination of lipophilicity non-steroidal anti-inflammatory agents and cephalosporin antibiotics in drugs and biological materials, have been reviewed.

[16-year experience with one-day surgery inguinal hernia repair].

Aim Of The Study: Evaluation of inguinal hernia repair techniques and results.

Material: Study group consist of patients undergoing inguinal hernia repair between 1990-1998 326 patients (305 men, 21 women, mean age 45.5 yrs), and between 1999-2006 693 patients (662 men, 31 women, mean age 48.

[Cryotherapy of liver tumors].

Aim Of The Study: To assess the value of cryodestruction during cytoreduction of liver tumors in the patients undergoing palliative treatment as well as evaluation of the frequency and type of complications of the method.

Patients And Method: Between 1990-2001, 33 cryodestruction of maligant tumors of liver were performed for primary tumor in 8 cases and for metastatic lesions in 25. Thirteen patients had single, and the remaining 20 multiple lesions in liver.

[Radiofrequency ablation of the primary and secondary liver malignancies].

For primary liver tumors and selected cases of colorectal liver metastases, surgical resection with preserved oncological margins of healthy tissue has been a method of choice. The criteria that decide about qualifying the patients to surgical resections include the number of nodules, size, localization, infiltrations to vessels or neighboring organs, liver functions, and patient's general condition. In fact, these criteria confine the number of performed resections to 5-25% of cases.