Publications by authors named "Jerzy Pyskir"

Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) may contribute to venous thromboembolism (VTE) with adverse effects on the course of COVID-19. The purpose of this study was to investigate an incidence and risk factors for VTE in patients hospitalized for COVID-19 in a non-intensive care unit (non-ICU). Consecutive adult patients with COVID-19 hospitalized from November 2021 to March 2022 in the isolation non-ICU at our center were included in the study.

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Several studies have indicated that COVID-19 can lead to alterations in blood rheology, including an increase in red blood cell aggregation. The precise mechanisms behind this phenomenon are not yet fully comprehended. The latest findings suggest that erythrocyte aggregation significantly influences microcirculation, causes the formation of blood clots in blood vessels, and even damages the endothelial glycocalyx, leading to endothelial dysfunction.

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Fluorescence lifetime measurements of blood or plasma offer valuable insights into the microenvironment and molecular interactions of fluorophores, particularly concerning albumin. Neutrophil- and hypoxia-induced oxidative stress in COVID-19 pneumonia patients leads to hyperinflammation, various oxidative modifications of blood proteins, and potential alterations in the fluorescence lifetime of tryptophan-containing proteins, especially albumin. The objective of this study was to investigate the efficacy of time-resolved fluorescence spectroscopy of blood and plasma as a prompt diagnostic tool for the early diagnosis and severity assessment of COVID-19-associated pneumonia.

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The aim of this study was to investigate the aggregation of red blood cells (RBCs) suspended in dextran solution at various levels of molecular mass. Dextran solutions at molecular mass 40, 70, 100 and 500 kDa at concentration from 2 to 5 g/dL were used to suspend the RBCs. The radius and velocity of sedimenting RBC aggregates were investigated using image analysis.

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A method of rapidly pointing out the risk of developing persistent pulmonary fibrosis from a sample of blood is extraordinarily needed for diagnosis, prediction of death, and post-infection prognosis assessment. Collagen scar formation has been found to play an important role in the lung remodeling following SARS-CoV-2 infection. For this reason, the concentration of collagen degradation products in plasma may reflect the process of lung remodeling and determine the extent of fibrosis.

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Article Synopsis
  • * A study of 66 hospitalized COVID-19 patients showed significantly elevated AOPPs levels during their acute infection, compared to their levels 6 and 12 months later, suggesting a link between oxidative stress and increased inflammation.
  • * The research found correlations between modified albumin levels and various inflammatory markers, indicating that oxidized albumin may play a crucial role in the disease process of COVID-19 and its potential consequences on health.
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The aim of this study was to examine the usefulness of time-resolved fluorescence spectroscopy in the evaluation of the oxidative processes in human plasma. To investigate the impact of oxidative stress on the fluorescence of plasma, five studied markers (thiobarbituric acid-reactive substances, ischemia modified albumin, carbonyl groups, hydrogen peroxide, advanced oxidation protein products) were chosen as oxidative damage approved markers. Our method presents several advantages over traditional methods as it is a direct, non-time-consuming, repeatable, and non-invasive technique that requires only simple pre-treatment of samples without additional reagents and the sample size needed for analysis is small.

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Patients with spinal cord injury (SCI) are at an increased risk of deep vein thrombosis (DVT). This study aims at assessing usefulness of D-dimer and compressive Doppler ultrasonography (CDUS) for detecting DVT in patients undergoing rehabilitation at various time-points post-SCI. One-hundred forty-five patients were divided into three groups based on time elapsed since SCI: I (≥3 weeks to 3 months), II (≥3 to 6 months), and III (≥6 months).

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The goal of this study was to measure hemostatic markers after SCI. Assesing changes in coagulation and fibrynilitic system in SCI patients in different time post injury to Cross-sectional study. Rehabilitation Department of the Bydgoszcz University Hospital, Poland from 2011 to 2017.

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Article Synopsis
  • - The study aimed to investigate the occurrence of deep venous thrombosis (DVT) in patients with chronic spinal cord injury (SCI) after three months of the injury.
  • - Conducted at a rehabilitation department in Poland, it involved 63 patients aged 13 to 65, with assessments including clinical evaluations and venous scans.
  • - Results showed DVT in 5 patients, with most cases occurring within 6 months post-injury, highlighting the continued risk for DVT in chronic SCI patients.
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For many years, the negative effects of cigarette smoking is a major social problem. The influence of smoking on various aspects of human life is intensively investigated, but still it is difficult to find studies on postural stability of smokers and non-smokers. Therefore, this paper attempts to analyse the results of the posturographic measurements in two groups of patients with the respiratory system diseases.

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The acting correctly immunological setting responds on every signal connected with appearing in the organism of the substance having of immunogenic properties. The smoking of cigarettes is connected with the continuous stimulation of the defensive mechanisms of the system both about the cellular character as and humoral. The important group of the proteins which he appears after immunostimulation in the intercellular space are particles built from the antigens of the various origin and antibodies.

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A harmful influence smoking on health is well known and documented. Smoking during pregnancy has negative influence not only on mothers but also on embryos. In spite of pregnancy is a very good reason to stop smoking only every third pregnant stop smoking during pregnancy.

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Allergies of the respiratory system are very often at children. Passive smoking may predispose to allergies. The last news shows that smoking at home increases incidence of asthma.

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The allergies of respiratory system are at children the frequent illnesses. Among favorable them factors, risk on passive smoking tobacco can be also. Passive smoking is defined as risk non-smoking on tobacco smoke in environment.

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