The impact of Triton WR-1339 induced hyperlipidemia on the effects of benzo(a)pyrene or guaiacol on α- and γ-tocopherol pools and selected markers of pro-/antioxidative balance in rat plasma and erythrocytes.

The toxicity of carcinogenic benzo(a)pyrene (BaP) can be intensified by the pro-oxidative effects of metabolic activation. The oxidatively active products can be formed during enzymatic biotransformation or in the process of co-oxygenation with lipid peroxidation. This study assesses if the acute hyperlipidemia can increase pro-oxidative effects of BaP as a factor intensifying processes of lipid peroxidation and co-oxygenation.

The impact of pharmaceutical care on patients with hypertension and their pharmacists.

Objective: The purpose of the study was to assess the influence of pharmaceutical care on patients' knowledge, quality of life and blood pressure and to determine whether new type of pharmaceutical services changes the pharmacists' satisfaction and knowledge.

Methods: Community pharmacies were randomly assigned to study and control group and pharmacists from both groups included patients with hypertension, who meet inclusion and exclusion criteria. Study group provided the pharmaceutical care (education, pharmacotherapy monitoring, detecting and solving drug related problems) for their patients, while the control group provided the standard pharmaceutical services (dispensing medicines with or without counseling).

Rapid HPLC method for the determination of vitamin A and E and cotinine concentration in human serum in women with CIN and cervical cancer.

Objective: The aim of this study was to elaborate on the analytical method for quantitative determination of retinol and alpha-tocopherol in serum of women diagnosed with CIN and cervical cancer. The basic problem in the analysis of the vitamins content in biological material is their low physiological concentration level and instability. Liquid chromatography with diode array detector (DAD) was applied.

[Preparation of a programme entitled "The role of pharmacists in providing support for nicotine replacement therapy in public pharmacies].

In the last years, the role of pharmacist in the community has changed considerably. Pharmacists became active patients' consultants and health confidants. Smoking is one of the most important risk factors for burden of disease and a major contributor to the death of millions of people each year.

[Assessment of the effectiveness of pharmacists' activities in treatment of tobacco-addicted patients in the context of pharmacists' counselling in Cracow's pharmacies].

Tobacco-related diseases killed 100 millions people in 20th century and unless urgent action is taken, it is predicted that 1 billion people in total will be killed by smoking in this century. Pharmacists as health-care professionals should support the healthy lifestyle campaign and motivate smokers to quit smoking especially as they have the theoretical basis for such counselling. The aims of the study were: 1.

[Competence of pharmacy students of the Jagiellonian University Medical College, Department of Pharmacy in Cracow in the problem of tobacco addiction].

Over 1.2 billion people in the world are addicted to tobacco products. Tobacco smoke contributes to increased risk cardiovascular diseases, respiratory diseases and development of cancers.

Collation, assessment and analysis of literature in vitro data on hERG receptor blocking potency for subsequent modeling of drugs' cardiotoxic properties.

The assessment of the torsadogenic potency of a new chemical entity is a crucial issue during lead optimization and the drug development process. It is required by the regulatory agencies during the registration process. In recent years, there has been a considerable interest in developing in silico models, which allow prediction of drug-hERG channel interaction at the early stage of a drug development process.

Antibacterial drug prescription for outpatients: age, seasonal and pulmonary disease dependency.

The goal of this study was to analyze antibacterial drug prescribing in the 1-million-plus, strictly defined population in Poland. For the 2002-2005 years, data from National Health Fund on outpatient purchasing of antibiotics in Lubuskie's Province were collected and expressed in DDD per 1-thousand inhabitants per day (DID). In the period 2002-2005 the average rate of antibiotics purchasing was 19.

Analysis of non-hospital antibacterial pharmacotherapy in Poland.

Objectives: The aim of this research was to analyze the antibacterial drug consumption pattern in a 1-million-plus strictly defined population in Poland. We assessed outpatient antibiotic sales (ATC J01) in relation to patient age and season of the year, and sought to determine the group of patients with the most frequent recurrence of bacterial diseases.

Methods: The Lubuskie Regional Unit of the National Health Fund (NHF) and the Central Statistical Office (GUS) were the main sources of data.

[Potentially inappropriate drugs for geriatric patients].

Objective: Drug-related mortality and morbidity concern mainly older people because of frequent poly-pathology and polytherapy among them. The objective of this study was to estimate the scale of taking potentially inappropriate prescription drugs (PIPDs) by home-dwelling, elderly patients in the Polish environment and to evaluate the influence of age/gender of the patient and the specialty/place of practice of the practitioner and their choice of them.

Methods: Data were collected in pharmacies in Cracow and Gorlice and their vicinity.

[Preparing pharmacists for participating in health promotion programs as exemplified by the smoking prevention program].

Health promotion is an interdisciplinary subject which glue together such sciences as medicine, psychology, sociology, social politics and many others. It appears to be the most interesting theme for the pharmacists. One of the most important problem carried in the drug-stores is the fight against the nicotine dependency, which gives the pharmacists a large field to show his knowledge and competence in helping people with the smoking problem.

Artificial neural network in pharmacoeconomics.

Pharmacoeconomics research identifies, measures, and compares the costs (resources consumed) and consequences of medical products and services, where at least one of the compared alternatives is pharmacotherapy. Pharmacoeconomics has been designed to enable the decision maker to identify the preferred choice among existing alternatives. The decisions are often important for the patients' lives on the one hand, and for payers on the other (where the payer is understood as the institution responsible for financial resources allocation).

[Usefulness of some databases in medical practice].

The following publication include results of thinking the matter over usefulness some computer, medical databases as well as Internet drug information resources. Quantity of medical software and Internet portals is not equal to quality, so it is necessary to order and classify medical electronic tools. It was bring MICROMEDEX databases system to readers attention, as a model, reference tool helpful in computer aided medicine.