Chagas Disease Diagnostic Practices at Four Major Hospital Systems in California and Texas.

Background: Chagas disease (CD) is a parasitic disease that affects ∼300 000 people living in the United States. CD leads to cardiac and/or gastrointestinal disease in up to 30% of untreated people. However, end-organ damage can be prevented with early diagnosis and antiparasitic therapy.

Towards the Classification of Error-Related Potentials using Riemannian Geometry.

The error-related potential (ErrP) is an event-related potential (ERP) evoked by an experimental participant's recognition of an error during task performance. ErrPs, originally described by cognitive psychologists, have been adopted for use in brain-computer interfaces (BCIs) for the detection and correction of errors, and the online refinement of decoding algorithms. Riemannian geometry-based feature extraction and classification is a new approach to BCI which shows good performance in a range of experimental paradigms, but has yet to be applied to the classification of ErrPs.

Balanced, Orientation-Dependent Dichoptic Masking in Cortex of Visually Normal Humans Measured Using Electroencephalography (EEG).

In the human visual system, cerebral cortex combines left- and right-eye retinal inputs, enabling single, comfortable binocular vision. In visual cortex, the signals from each eye inhibit one another (interocular suppression). While this mechanism may be disrupted by e.

Auranofin Resistance in Decreases the Accumulation of Reactive Oxygen Species but Does Not Target Parasite Thioredoxin Reductase.

Auranofin, a reprofiled FDA-approved drug originally designed to treat rheumatoid arthritis, has emerged as a promising anti-parasitic drug. It induces the accumulation of reactive oxygen species (ROS) in parasites, including . We generated auranofin resistant lines through chemical mutagenesis to identify the molecular target of this drug.

Treatment for seasonal allergic rhinitis by Chinese herbal medicine: a randomized placebo controlled trial.

Context: Chinese herbal medicine (CHM) is widely used to treat seasonal allergic rhinitis (SAR), however, evidence of efficacy is lacking.

Objective: To evaluate the efficacy of a Chinese herbal formulation for the treatment of SAR.

Design: Randomized, double blind, placebo controlled trial.

Regulator of G protein signaling Z1 (RGSZ1) interacts with Galpha i subunits and regulates Galpha i-mediated cell signaling.

Regulator of G protein signaling (RGS) proteins constitute a family of over 20 proteins that negatively regulate heterotrimeric G protein-coupled receptor signaling pathways by enhancing endogenous GTPase activities of G protein alpha subunits. RGSZ1, one of the RGS proteins specifically localized to the brain, has been cloned previously and described as a selective GTPase accelerating protein for Galpha(z) subunit. Here, we employed several methods to provide new evidence that RGSZ1 interacts not only with Galpha(z,) but also with Galpha(i), as supported by in vitro binding assays and functional studies.

Effect of acupuncture in the treatment of seasonal allergic rhinitis: a randomized controlled clinical trial.

The clinical efficacy and safety of acupuncture in the treatment of Seasonal Allergic Rhinitis (SAR) was evaluated by employing a two-phase crossover single-blind clinical trial. Thirty subjects were randomly assigned to two groups with 17 and 13 subjects respectively and treated with real or sham acupuncture (three times per week) for four consecutive weeks and then a crossover for treatments for a further four weeks without a washout period. The administration of real acupuncture treatment was guided by a syndrome differentiation according to Chinese Medicine Theory.