Publications by authors named "Jerry Clark"
Perioperative management of implantable cardioverter-defibrillators is an important part of anesthetic care. Society recommendations and expert consensus statements exist to aid clinicians, and they have identified the umbilicus as an important landmark in decision-making. Implantable cardioverter-defibrillator antitachycardia therapy may not need to be deactivated for infraumbilical surgery because electromagnetic interference is unlikely to occur.
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- Development of sasanlimab, an anti-PD-1 antibody, shows potential for cancer immunotherapy by selectively blocking PD-1 interactions with PD-L1 and PD-L2, enhancing T-cell activity.
- Sasanlimab has demonstrated a stable high-affinity binding to PD-1 and significantly improved T-cell proliferation and cytokine production in laboratory tests.
- Nonclinical studies indicate that sasanlimab is effective in treating tumors and is well-tolerated in cynomolgus monkeys, supporting its clinical development for advanced cancer treatments.
A new reagent for the deprotection of aromatic methyl ethers, 2-(diethylamino)ethanethiol, is reported. This compound, commercially available as its HCl salt, affords the corresponding phenols in good to excellent yields on a wide variety of substrates. A clear advantage of this method over the use of more common thiols, such as ethanethiol, is the easy extraction of both the deprotecting reagent and the byproduct 2-(diethylamino)ethyl methyl sulfide into the aqueous phase by quenching with dilute acid, which allows an essentially odorless workup.
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