Publications by authors named "Jerry Cheng-Yen Lai"

Objective: Gestational diabetes mellitus (GDM) is a disorder that can occur during the second trimester of pregnancy. Our main objective was to perform a retrospective propensity-score matched analysis of a general population and to examine commonly occurring adverse maternal and infant outcomes in Taiwanese primiparous women with GDM.

Materials And Methods: We conducted a nationwide population-based, retrospective propensity-score matched cohort study using the claims data from the Taiwan's National Health Insurance program between 2000 and 2015.

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  • The study investigated how three-dimensional rehabilitation potential affects daily living activities in stroke patients during their rehabilitation.
  • It involved 101 participants with strokes in two rehabilitation wards in Northern Taiwan and measured various rehabilitation factors, including biological, psychological, and social aspects.
  • Findings indicated that poor swallowing ability, low muscle power, urinary incontinence, and lower motivation significantly impacted rehabilitation success, with stronger swallowing ability and motivation leading to better daily living outcomes over time.
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Histamine modulates immunity by binding to histamine receptor 2 (H2R). Cimetidine, an H2R antagonist that inhibits gastric acid secretion and treats gastrointestinal ulcers, interferes with histamine-mediated immunomodulation and may have anticancer activity. This study examined cimetidine's effect on the anticancer effect of anti-PD-L1 in colon cancer.

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Introduction: The global tobacco epidemic poses a notable challenge to global health due to its association with various tobacco-related diseases. Although tobacco smoking is associated with depression, the exact mechanism by which tobacco smoking increases the risk of depression is unclear. This study explored the potential effects of tobacco smoking on depression.

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Background: Electroencephalographic pattern changes during anesthesia reflect the nociception-analgesia balance. Alpha dropout, delta arousal, and beta arousal with noxious stimulation have been described during anesthesia; however, data on the reaction of other electroencephalogram signatures toward nociception are scarce. Analyzing the effects of nociception on different electroencephalogram signatures may help us find new nociception markers in anesthesia and understand the neurophysiology of pain in the brain.

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Many studies have reported positive contributions of health promotion on the health behavior of nursing staff working in hospitals, including the maintenance of a regular healthy diet, engagement in physical activity, performance of routine screening practices, and participation in a health examination. Despite being considered a role model for healthy lifestyles, little is known about the effect of health-promoting hospital settings on nursing staff. The aim of this study was to perform a nationwide, hospital-based, cross-sectional, survey comparing health practices between full-time nurses of health-promoting hospitals and those of non-health-promoting hospitals in Taiwan.

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  • A study of 23,628 adults analyzed how coffee consumption affects lipid profiles, focusing on differences between men and women, particularly premenopausal and postmenopausal women.
  • The research found that individuals who drank more coffee had higher total cholesterol and LDL cholesterol, but lower triglycerides compared to non-coffee drinkers.
  • Results suggest that menopausal status influences the effects of coffee on lipid levels, with premenopausal women potentially benefitting the most from regular coffee consumption.
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Objective: This study aimed to examine the mediating effect of swallowing ability on hemoglobin levels and activities of daily living (ADL).

Design: Prospective longitudinal study.

Setting: Two rehabilitation wards in a national referral center for Northern Taiwan, followed by discharge.

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Background: Sociocultural factors play critical roles in the mental health of marriage-based immigrant women. However, the effect of bi-dimensional acculturation ("adaptation to host culture" and "maintenance of heritage culture") and social support on perinatal depression across time was unknown among them.

Objective: To examine the effect of bi-dimensional acculturation and social support on perinatal depression among marriage-based immigrant women in Taiwan.

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Previous studies revealed inconsistent results between coffee drinking and metabolic syndrome (MetS). The aim of the study was to evaluate the relationship between habitual coffee drinking and the prevalence of MetS among men and women. We conducted a nationwide, cross-sectional study using 23,073 adults obtained from the Taiwan Biobank database (mean ± SD (range) age, 54.

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Few studies compared the effects of non-fermented and fermented tea among the general population. We aimed to compare the risk of incident osteoporosis (OP) between non-fermented tea and fermented tea drinkers by this retrospective nationwide population-based analysis from the Taiwan Biobank. Participants ≥ 40 years who drink fermented tea (n = 2205) were compared with those who drink non-fermented tea (n = 1034) from 2008 to 2015 with a mean follow-up period of 3.

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Background And Purpose: Health-seeking behavior has a direct impact on individual's health. A proper understanding of patients' demographics and health factors is essential in constructing high-quality health care services toward Chinese or Western medicine. The objective of this study was to understand the tendency among Taiwanese to opt for either Chinese or Western medicine when both services are available.

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Background: In 2011, the American Academy of Pediatrics recommended universal lipid screening during childhood and adolescence. However, this approach was shown to be lacking in adherence. Only 6% of non-high-risk children received lipid screening by age 12.

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  • The research developed an Oncofertility Barrier Scale (OBS) to assess barriers affecting oncofertility care in breast cancer treatment, addressing a gap in valid assessment tools for healthcare providers.
  • The OBS underwent rigorous validation processes, including expert reviews and factor analysis, resulting in a six-factor model that highlights key barriers such as lack of education and insufficient support.
  • The final 27-item OBS demonstrated strong reliability and validity, making it a useful tool for both research and clinical settings to identify and address barriers in fertility care for cancer patients.
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  • The study investigates the relationship between the GP.Mur red blood cell type and blood pressure, specifically how it may influence blood pressure levels in adults.
  • Researchers analyzed data from 989 non-elderly adults, focusing on factors like BMI, age, and hemoglobin levels to determine their impact on blood pressure.
  • Results showed GP.Mur slightly increased systolic blood pressure, particularly in non-anemic Taiwanese men, but the contribution of GP.Mur to blood pressure was both hemoglobin-dependent and independent, with further research needed to fully understand its mechanisms.
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Introduction: Marriage-based immigrant women are increasing around the world. Although bi-dimensional acculturation is important for immigrant women's health, the existing scales have mainly been developed for immigrant women in Western countries and hence some items may not be suitable for Asian contexts. Thus, we developed and evaluated the Bidimensional Acculturation Scale for Marriage-Based Immigrant Women (BAS-MBIW) in Taiwan.

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Introduction: Osteoporosis is major public health concern, but the long-term impacts of tobacco and alcohol consumption on its development are unclear. This study analyzed the relationship between tobacco and alcohol use and osteoporosis by using data from the Taiwan Biobank (TWB), established in 2012.

Methods: Participants in TWB were included in our study, with a total of 18394 respondents included for analysis.

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Background: Childbirth may pose many challenges to the psychological well-being of marriage-based immigrant mothers in interracial marriages, who must negotiate bi-dimensional acculturation - adaptation to the host culture and maintenance of her own heritage culture. We examined the temporal relationships between bi-dimensional acculturation and depressive symptoms from pregnancy to 1 year postpartum among marriage-based immigrant mothers in Taiwan using the cross-lagged structural equation modeling.

Methods: This study recruited 310 immigrant mothers, who were examined in the second and third trimesters, and again at 1 month, 3 months, 6 months, and 1 year postpartum from March 2013 to December 2015.

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Background: Traditional Chinese medicine (TCM) appears to be the common therapy in middle-aged women. The constitution serves as a guide for TCM treatment. However, little is known about the constitution and related factors in middle-aged women.

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TLC388, a camptothecin-derivative targeting topoisomerase I, is a potential anticancer drug. In this study, its effect on A549 and H838 human non-small cell lung cancer (NSCLC) cells was investigated. Cell viability and proliferation were determined by thiazolyl blue tetrazolium bromide and clonogenic assays, respectively, and cell cycle analysis and detection of phosphorylated histone H3 (Ser10) were performed by flow cytometry.

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Aim: The purposes of this study were to describe the degree of knowledge and explore the factors associated with knowledge of infertility among women of childbearing age with breast cancer.

Methods: In this cross-sectional study, we recruited women of childbearing age with a diagnosis of breast cancer who had completed chemotherapy at a hospital in Taipei from 2015 through 2016. Face-to-face interviews were completed with 201 (62%) of 324 eligible women, asking about sociodemographic variables, disease and treatment characteristics, fertility intention, and infertility-related knowledge.

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Background: Infertility is negatively related to the quality of life in reproductive-age women with breast cancer. The nurses who care for these patients lack a comprehensive understanding of the changes in fertility intention that patients undergo from the time of cancer diagnosis, throughout treatment, and after treatment. A fertility intention assessment is the first step in discerning the patient's ideas toward future pregnancy.

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Objective: To examine and describe the use of Western and Chinese Medicine for pregnancy preparation among women with breast cancer after cancer-related treatment in Taiwan.

Methods: Women of reproductive age (20-49 years) women who were treated for breast cancer from January 2011 through June 2015 in a Taiwanese city participated in the study. Of 306 eligible study participants, interviews were completed in 197 (64%).

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The presence of pelvic lymph node metastases is without doubt the most significant prognostic factor that determines recurrences and survival of women with early-stage cervical cancer. To avoid the underdiagnosis of lymph node metastasis, pelvic lymphadenectomy procedure is routinely performed with radical hysterectomy procedure. However, the pelvic lymphadenectomy procedure may not be necessary in most of these women due to the relatively low incidence of pelvic lymph node metastasis.

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  • Pelvic lymphadenectomy is a standard part of radical hysterectomy for early-stage cervical cancer, but it can lead to lymphedema, causing emotional issues like depression and anxiety in affected women.
  • Research indicates that only around 10% of clinical stage IB cervical cancer patients have metastatic disease, suggesting there’s potential to limit lymphadenectomy to only those with regional nodal metastasis.
  • Sentinel lymph node biopsy shows promising outcomes in detecting lymph node involvement, possibly improving quality of life and preventing unnecessary surgeries for women with early-stage cervical cancer.
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