External Validation of the Radiographic Investigation of the Distal Extension of Fractures Into the Articular Surface of the Tibia (RIDEFAST Study).

Objective: To test the external validity of the fracture to plafond (FTP-length of fracture/distance to plafond) ratio to rule out distal intra-articular fractures (DIA) in distal tibial shaft fractures at an independent tertiary trauma center.

Design: Retrospective cohort study.

Setting: Two Level 1 trauma centers.

Comparing Diagnostic and Treatment Recommendations of Carpal Tunnel Syndrome Available on the Internet With AAOS Clinical Practice Guidelines.

Carpal tunnel syndrome (CTS) is one of the most common diagnoses in a hand surgeon's office, with estimated cost exceeding US $2 billion annually in the United States. Due to this prevalence and cost, patients often turn to the Internet for their medical care. It has been estimated that 72% of Internet users have looked online for health information in the last year.

Acute Perioperative Comparison of Patient-Specific Instrumentation versus Conventional Instrumentation Utilization during Bilateral Total Knee Arthroplasty.

Utilizing patient-specific instrumentation during total knee arthroplasty has gained popularity in recent years with theoretical advantages in blood loss, intraoperative time, length of stay, postoperative alignment, and functional outcome, amongst others. No study has compared acute perioperative measures between patient-specific instrumentation and conventional instrumentation in the bilateral total knee arthroplasty setting. We compared patient-specific instrumentation versus conventional instrumentation in the setting of bilateral total knee arthroplasty to determine any benefits in the immediate perioperative period including surgical time, blood loss, pain medication use, length of stay, and discharge disposition.

L-Arginine Supplementation in Type II Diabetic Rats Preserves Renal Function and Improves Insulin Sensitivity by Altering the Nitric Oxide Pathway.

Rat studies demonstrated that type II diabetes mellitus (T2DM) decreases both the production and bioavailability of nitric oxide (NO). L-arginine (LA) provides the precursor for the production of NO. We hypothesized that LA dietary supplementation will preserve NO production via endothelial nitric oxide synthase (eNOS) causing renal microvascular vasodilation and increased glomerular blood flow and thus increasing glomerular filtration rate (GFR).