Semi-invasive therapies for pain in knee osteoarthritis: A systematic review and network meta-analysis.

Background: The increasing number of semi-invasive pain therapies in knee osteoarthritis poses challenges in decision-making. This review aimed to simultaneously compare established intra-articular therapies with newer peri-articular therapies and explore effect modifiers.

Methods: Randomized controlled trials were searched from five electronic databases without date or language restrictions.

Determinants of High Fasting Insulin and Insulin Resistance Among Overweight/Obese Adolescents.

Hyperinsulinaemia is the earliest subclinical metabolic abnormality, which precedes insulin resistance in obese children. An investigation was conducted on the potential predictors of fasting insulin and insulin resistance among overweight/obese adolescents in a developing Asian country. A total of 173 overweight/obese (BMI > 85 percentile) multi-ethnic Malaysian adolescents aged 13 were recruited from 23 randomly selected schools in this cross-sectional study.