Publications by authors named "Jerome Wu"
Coherence time is one of the fundamental characteristics of light sources. Methods based on autocorrelation have been widely applied from optical domain to soft X-rays to characterize the radiation coherence time. However, for the hard X-ray regime, due to the lack of proper mirrors, it is extremely difficult to implement such autocorrelation scheme.
View Article and Find Full Text PDFOne of the key challenges in scientific researches based on free-electron lasers (FELs) is the characterization of the coherence time of the ultra-fast hard x-ray pulse, which fundamentally influences the interaction process between x-rays and materials. Conventional optical methods, based on autocorrelation, are very difficult to realize due to the lack of mirrors. Here, we experimentally demonstrate a novel method which yields a coherence time of 174.
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- Kv1.1 channels are found in various brain and spinal cord regions and contribute to neuron hyperpolarization when expressed alone, but co-expression with Kvbeta1 switches them to a fast inactivating current, increasing neuron excitability.
- A yeast two-hybrid screen was used to find compounds that prevent Kv1.1 inactivation by Kvbeta1, identified as 'disinactivators,' which also showed potential in reducing seizure activity in mice.
- These disinactivators work through various mechanisms, likely interacting with the Kvbeta1 N-terminus or its binding site on Kv1.1, offering a possible treatment strategy for conditions like epilepsy and neuropathic pain.