Publications by authors named "Jerome Toffin"
BMC Cancer
September 2014
Article Synopsis
- Mutations in the BRAF gene are found in about 50% of melanomas, with the selective BRAF inhibitor vemurafenib showing effectiveness against common mutations like V600E, V600K, and V600R.
- A patient with a rare BRAF mutation (p.V600_K601delinsD) was treated with vemurafenib and showed a positive response, revealing two months of progression-free survival.
- The findings indicate that even rare BRAF mutations can respond to vemurafenib, highlighting the need for molecular screening that includes these atypical mutations.
