Targeting metastasis-initiating cancer stem cells in gastric cancer with leukaemia inhibitory factor.

Gastric cancer's (GC) bad prognosis is usually associated with metastatic spread. Invasive cancer stem cells (CSC) are considered to be the seed of GC metastasis and not all CSCs are able to initiate metastasis. Targeting these aggressive metastasis-initiating CSC (MIC) is thus vital.

Repurposing Dihydropyridines for Treatment of Infection.

Antibiotic resistance is a major cause of the increasing failures in the current eradication therapies against . In this scenario, repurposing drugs could be a valuable strategy to fast-track novel antimicrobial agents. In the present study, we analyzed the inhibitory capability of 1,4-dihydropyridine (DHP) antihypertensive drugs on the essential function of the response regulator HsrA and investigated both the in vitro antimicrobial activities and the in vivo efficacy of DHP treatments against .