Choice of antipsychotic treatment by European psychiatry trainees: are decisions based on evidence?

Background: Little is known about the factors influencing treatment choice in psychosis, the majority of this work being conducted with specialists (consultant) in psychiatry. We sought to examine trainees' choices of treatment for psychosis if they had to prescribe it for themselves, their patients, and factors influencing decision-making.

Methods: Cross-sectional, semi-structured questionnaire-based study.

Stimulated gene expression profiles as a blood marker of major depressive disorder.

Background: Major depressive disorder (MDD) is a moderately heritable disorder with a high lifetime prevalence. At present, laboratory blood tests to support MDD diagnosis are not available.

Methods: We used a classifier approach on blood gene expression profiles of a unique set of unmedicated subjects (MDD patients and control subjects) to select genes with expression predictive for disease status.