The role of the alpha 2A-adrenoceptor in mouse stress-coping behaviour.

Acute stress is known to impair memory functions in both men and laboratory rodents. In human the alpha 2A-adrenoceptor system is known to play a critical role in regulating acute neuropsychological stress responses and, ultimately, stress-coping behaviour. In search for neurobiological and central nervous mechanisms behind these behaviours we investigated if the alpha 2A-adrenoceptor is involved in these mechanisms in mice.