Publications by authors named "Jeroen O Lohuis"
Article Synopsis
- The oestrous cycle significantly affects breast cancer's response to neoadjuvant chemotherapy (NAC), with treatment during the dioestrus stage resulting in less effectiveness compared to the oestrus stage.
- In mouse models and human premenopausal cohorts, dioestrus is associated with increased chemoresistance, characterized by more cells undergoing epithelial-to-mesenchymal transition, narrower tumor blood vessels, and higher macrophage levels.
- Understanding the impact of the oestrous cycle on treatment response could lead to improved timing for chemotherapy, enhancing patient outcomes.
Although treatment with taxanes does not always lead to clinical benefit, all patients are at risk of their detrimental side effects such as peripheral neuropathy. Understanding the in vivo mode of action of taxanes can help design improved treatment regimens. Here, we demonstrate that in vivo, taxanes directly trigger T cells to selectively kill cancer cells in a non-canonical, T cell receptor-independent manner.
View Article and Find Full Text PDFThe metastatic process of colorectal cancer (CRC) is not fully understood and effective therapies are lacking. We show that activation of NOTCH1 signaling in the murine intestinal epithelium leads to highly penetrant metastasis (100% metastasis; with >80% liver metastases) in Kras-driven serrated cancer. Transcriptional profiling reveals that epithelial NOTCH1 signaling creates a tumor microenvironment (TME) reminiscent of poorly prognostic human CRC subtypes (CMS4 and CRIS-B), and drives metastasis through transforming growth factor (TGF) β-dependent neutrophil recruitment.
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