Publications by authors named "Jeroen Jg Geurts"
Background: Synaptic and neuronal loss contribute to network dysfunction and disability in multiple sclerosis (MS). However, it is unknown whether excitatory or inhibitory synapses and neurons are more vulnerable and how their losses impact network functioning.
Objective: To quantify excitatory and inhibitory synapses and neurons and to investigate how synaptic loss affects network functioning through computational modeling.
Background: Upper and lower limb disabilities are hypothesized to have partially independent underlying (network) disturbances in multiple sclerosis (MS).
Objective: This study investigated functional network predictors and longitudinal network changes related to upper and lower limb progression in MS.
Methods: Two-hundred fourteen MS patients and 58 controls underwent functional magnetic resonance imaging (fMRI), dexterity (9-Hole Peg Test) and mobility (Timed 25-Foot Walk) measurements (baseline and 5 years).
Background: Cognitive training elicits mild-to-moderate improvements in cognitive functioning in people with multiple sclerosis (PwMS), although response heterogeneity limits overall effectiveness.
Objective: To identify patient characteristics associated with response and non-response to cognitive training.
Methods: Eighty-two PwMS were randomized into a 7-week attention training ( = 58, age = 48.
Background: Cognitive impairment occurs in the earliest stages of multiple sclerosis (MS) together with altered functional connectivity (FC).
Objective: The aim of this study was to investigate the evolution of dynamic FC states in early MS and their role in shaping cognitive decline.
Methods: Overall, 32 patients were enrolled after their first neurological episode suggestive of MS and underwent cognitive evaluation and resting-state functional MRI (fMRI) over 5 years.
Background: The feasibility of cognitive rehabilitation is rarely investigated in patients with advanced multiple sclerosis.
Methods: Eighteen patients with advanced multiple sclerosis (median EDSS = 7.5) were randomized into restorative or compensatory cognitive rehabilitation.
Neuropsychological test scores in people with MS (PwMS) do not fully reflect cognitive functioning in daily life. Therefore, we developed a questionnaire based on instrumental activities of daily living (IADL), using the Amsterdam IADL-Q for Alzheimer's disease as starting point. Forty-eight items were evaluated on relevance and clarity by (inter)national experts (n = 30), PwMS (n = 61) and proxies (n = 30).
View Article and Find Full Text PDFBackground: Cortical lesions are highly inconspicuous on magnetic resonance imaging (MRI). Double inversion recovery (DIR) has a higher sensitivity than conventional clinical sequences (i.e.
View Article and Find Full Text PDFBackground: Thalamic atrophy is proposed to be a major predictor of disability progression in multiple sclerosis (MS), while thalamic function remains understudied.
Objectives: To study how thalamic functional connectivity (FC) is related to disability and thalamic or cortical network atrophy in two large MS cohorts.
Methods: Structural and resting-state functional magnetic resonance imaging (fMRI) was obtained in 673 subjects from Amsterdam (MS: = 332, healthy controls (HC): = 96) and Graz (MS: = 180, HC: = 65) with comparable protocols, including disability measurements in MS (Expanded Disability Status Scale, EDSS).
Background: The impact of cerebellar damage and (dys)function on cognition remains understudied in multiple sclerosis.
Objective: To assess the cognitive relevance of cerebellar structural damage and functional connectivity (FC) in relapsing-remitting multiple sclerosis (RRMS) and secondary progressive multiple sclerosis (SPMS).
Methods: This study included 149 patients with early RRMS, 81 late RRMS, 48 SPMS and 82 controls.
Article Synopsis
- Cognitive decline in multiple sclerosis (MS) patients is challenging to predict as structural brain damage alone doesn't account for the variability among patients.
- This study aimed to see if measuring functional brain network organization through magnetoencephalography (MEG) can better predict cognitive decline in MS patients over five years, beyond just looking at physical brain damage.
- Results showed that a more integrated beta band network and a less integrated delta band network were both linked to cognitive decline, suggesting that these functional brain network measures could serve as valuable predictors for disease progression in MS.
Background: Network abnormalities could help explain physical disability in multiple sclerosis (MS), which remains poorly understood.
Objective: This study investigates functional network efficiency changes in the sensorimotor system.
Methods: We included 222 MS patients, divided into low disability (LD, Expanded Disability Status Scale (EDSS) ⩽3.
Objective: To directly compare the efficacy of natalizumab and fingolimod in patients with active relapsing-remitting multiple sclerosis.
Methods: This phase 4, randomised, rater- and sponsor-blinded, prospective, parallel-group, clinic-based head-to-head study was conducted at 43 sites in nine countries. Patients were randomised (1:1) to intravenous natalizumab 300 mg every 4 weeks or oral fingolimod 0.
Background: Neuroaxonal degeneration is one of the hallmarks of clinical deterioration in progressive multiple sclerosis (PMS).
Objective: To elucidate the association between neuroaxonal degeneration and both local cortical and connected white matter (WM) tract pathology in PMS.
Methods: 3T magnetic resonance imaging (MRI) and cortical tissue blocks were collected from 16 PMS donors and 10 controls.
Objective: The objective of the study was to determine whether early infratentorial and/or spinal cord lesions are long-term cumulative predictors of disability progression in multiple sclerosis (MS).
Methods: We selected 153 MS patients from the longitudinal Amsterdam MS cohort. Lesion analysis was performed at baseline and year 2.
Background/objective: Endurance exercise can improve memory function in persons with multiple sclerosis (pwMS), but the effects on hippocampal functioning are currently unknown. We investigated the effects of a running intervention on memory and hippocampal functional connectivity in pwMS.
Methods/results: Memory and resting-state functional magnetic resonance imaging (fMRI) data were collected in a running intervention ( = 15) and waitlist group ( = 14).
Background: Neurophysiological measures of brain function, such as magnetoencephalography (MEG), are widely used in clinical neurology and have strong relations with cognitive impairment and dementia but are still underdeveloped in multiple sclerosis (MS).
Objectives: To demonstrate the value of clinically applicable MEG-measures in evaluating cognitive impairment in MS.
Methods: In eyes-closed resting-state, MEG data of 83 MS patients and 34 healthy controls (HCs) peak frequencies and relative power of six canonical frequency bands for 78 cortical and 10 deep gray matter (DGM) areas were calculated.
Background: The biological mechanism of depression in multiple sclerosis (MS) is not well understood. Based on work in major depressive disorder, fronto-limbic disconnection might be important.
Objective: To investigate structural and functional fronto-limbic changes in depressed MS (DMS) and non-depressed MS (nDMS) patients.
Background: The presence of asymptomatic spinal cord (SC) lesions in patients with clinically isolated syndrome (CIS) or relapsing-remitting multiple sclerosis (RRMS) predicts conversion to clinically definite multiple sclerosis (CDMS). The relation between asymptomatic SC abnormalities and disability progression warrants further investigation.
Objective: To determine the prognostic value of asymptomatic SC lesions in CIS and early RRMS with respect to the time to disability development.
Background: Cerebellar lesions are often reported in relapsing-remitting multiple sclerosis (RRMS) and have been associated with impaired motor function and cognitive status. However, prior research has primarily focused on summary measures of cerebellar involvement (e.g.
View Article and Find Full Text PDFBackground: Multiple sclerosis is characterized by white matter lesions, which are visualized with conventional T2-weighted magnetic resonance imaging (MRI). Little is known about local metabolic processes preceding the appearance and during the pathological development of new lesions.
Objective: To identify metabolite changes preceding white matter (WM) lesions and pathological severity of lesions over time.
Background: Using diffusion tensor imaging (DTI), it was previously found that demyelinated gray matter (GM) lesions have increased fractional anisotropy (FA) when compared to normal-appearing gray matter (NAGM) in multiple sclerosis (MS). The biological substrate underlying this FA change is so far unclear; both neurodegenerative changes and microglial activation have been proposed as causal contributors.
Objective: To test the proposed hypothesis that microglia activation is responsible for increased FA in cortical GM lesions.
Background: Lesions with different extents of myelin pathology are found at autopsy in multiple sclerosis (MS), but the differences are not discernible in magnetic resonance imaging (MRI).
Objective: To determine whether analysis of the local spectrum in MRI is sensitive to lesion differences in myelin integrity.
Methods: We imaged fresh brain slices from 21 MS patients using 1.