Stabilizing human regulatory T cells for tolerance inducing immunotherapy.

Many autoimmune diseases develop as a consequence of an altered balance between autoreactive immune cells and suppressive FOXP3 Treg. Restoring this balance through amplification of Treg represents a promising strategy to treat disease. However, FOXP3 Treg might become unstable especially under certain inflammatory conditions, and might transform into proinflammatory cytokine-producing cells.