Sputum inflammatory, neural, and remodeling mediators in eosinophilic and noneosinophilic asthma.

Background: Neural and remodeling mechanisms may play a role in asthma, particularly noneosinophilic asthma (NEA).

Objective: To assess sputum mediators associated with neural, remodeling, and inflammatory mechanisms in eosinophilic asthma (EA), NEA, and participants without asthma.

Methods: A total of 111 participants with and 62 without asthma (14-21 years old) underwent sputum induction, exhaled nitric oxide, atopy, and spirometry tests.