Publications by authors named "Jernigan A"

Objective: There is no standard clinical trial screening process in gynecologic oncology. In our low resource, highly diverse gynecologic oncology patient population, we sought to create an equitable, adaptable, manual screening process.

Methods: Our objective is to describe our clinical trial screening process and success in improving trial enrollment.

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Objective: Food insecurity is becoming recognized as an important measure of public health. Louisiana has a poorer health index and a higher food insecurity rate than the national average. This study aims to investigate how living in a food desert affects the stage at diagnosis and 5-year overall survival in patients with gynecologic cancers.

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Knowledge of how agricultural management interacts with weed seed banks and emergent weed communities is crucial for proactive weed management. Though studies have detailed how differences in disturbance and nutrient applications between organic and conventional herbicide-based systems affect weed communities, few have focused on these same factors in contrasting organic systems. This study assessed the seed banks and emergent weed communities from the most recent crop rotation cycle (2017-2022) of a long-term experiment, which compared four organic grain and forage cropping systems differing in nutrient inputs and soil disturbance.

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Article Synopsis
  • Endometrial cancer (EC) is closely linked to obesity, particularly affecting young women, and identifying it early can improve treatment options, especially for those with severe obesity undergoing metabolic/bariatric surgery.
  • A screening program using a modified questionnaire, called Modified SAMANTA, was implemented to identify women with abnormal or postmenopausal uterine bleeding (APUB) before their surgery to check for possible underlying endometrial issues.
  • Over a study period from March 2021 to May 2023, nearly half of the 1371 women screened were found to have APUB, with higher prevalence linked to factors like increased BMI and certain racial demographics, highlighting the need for careful monitoring in these patients.*
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Pancreatitis, panniculitis, and polyarthritis (PPP) syndrome presents a unique challenge in diagnosis and management because of its rarity and heterogeneous initial presentation. This manuscript presents a case series of two patients with PPP syndrome, shedding light on the diagnostic process and care for this uncommon condition. PPP syndrome is characterized by the simultaneous occurrence of pancreatitis or pseudocysts alongside polyarthritis and panniculitis.

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Objectives: Use of Synthetic and designer products, including synthetic marijuana (SM), among adolescents poses a major risk to public health. Little is known about the motivating factors of synthetic substance use in adolescents. This study examined the motivations, predictors, perceived risks and benefits, and differences with SM versus natural marijuana among adolescents.

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Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but severe dermatologic immune-related adverse events (irAEs) characterized by the separation of the epidermal and dermal layers of the skin. Less commonly documented, these adverse events have shown to be secondary to immune checkpoint inhibitors such as anti-PD-1 monoclonal antibody pembrolizumab. We present the case of a 33-year-old African American female with a pertinent past medical history of history of recurrent progressive metastatic squamous cell carcinoma cervical cancer treated with pembrolizumab.

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Article Synopsis
  • Obesity is a big problem around the world and can lead to serious diseases like diabetes and cancer, but many people with obesity don’t get the help they need.
  • One of the best treatments for obesity is metabolic and bariatric surgery, which is shown to be safe and can help reduce the risk of certain cancers, especially endometrial cancer.
  • People who have endometrial cancer and are also obese are more likely to have other health issues, so surgery may help them stay healthier and survive longer, and doctors should look for those who might benefit.
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Background: Enhanced recovery after surgery (ERAS) protocols improve outcomes. We investigated ERAS implementation in a population with comorbid conditions, inadequate insurance, and barriers to healthcare undergoing gynecologic surgery.

Objective: To investigate ERAS implementation in publicly insured/uninsured patients undergoing gynecologic surgery on hospital length of stay (LOS), 30-day hospital readmission rates, opioid administration, and pain scores.

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Objectives: To evaluate images of vulvar conditions (VCs) in major gynecologic textbooks and describe the skin tone representation.

Methods: Images of VCs in gynecological textbooks for medical students, obstetrics and gynecology (OBG) residents, and fellows were compiled. Texts were categorized into education levels (medical student, resident, or fellow) and selected based on the recommendations of OBG attendings and fellows at LSUHSCNew Orleans.

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Authorship confers credit to those responsible for a publication. In 1985, the International Committee of Medical Journal Editors criteria were founded to standardize authorship assignment. We sought to investigate practices and values in authorship assignment in Society of Gynecologic Oncology (SGO) members.

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Article Synopsis
  • The study aimed to assess the rates of MMRd or MSI-H endometrial cancer (EC) tumors, prevalence of Lynch Syndrome (LS), and the adherence to genetic evaluation guidelines among women with EC from 2013 to 2019.
  • Among 286 women, 27.5% of the 80 tested tumors were MMRd or MSI-H, while no LS cases were found in the 21 women who underwent germline testing.
  • After NCCN's universal tumor testing recommendation, testing rates rose from 17.6% to 60%, with advanced cancer stage linked to a higher likelihood of testing, highlighting the need to improve care protocols despite no disparities in evaluation identified.
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Introduction: Risk-reducing salpingo-oophorectomy has been established as one of the most effective strategies in risk reduction for ovarian and breast cancers among women at increased genetic risk. However, there are limited data regarding the single-port laparoscopic platform in the field of risk-reducing surgery. Our objective was to describe outcomes after single-port risk-reducing salpingo-oophorectomy with or without hysterectomy for reduction of ovarian, breast, or endometrial cancer risk.

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Breast and gynecological cancers affect almost 900,000 women and therefore most health care providers will be involved at some point in the management of women with cancer. As the prognosis of all cancers is much more favorable when diagnosed in early stages, it is imperative that all health care providers are familiar not only with current screening guidelines for the average population, but also with the identification of high risk individuals who may benefit from more intense screening as well as available interventions to prevent disease or decrease risk. The purpose of this review article is to provide relevant information to physicians and other health care providers to aid in identifying patients that are classified as "high risk" for developing breast or a gynecologic cancer, outlining what interventions exist for adequate screening and risk reduction strategies, and to provide an update on current screening guidelines for individuals at average and high risk.

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Background: Minimally invasive hysterectomy is the standard of care in the majority of women diagnosed with endometrial cancer via robotic-assisted, multiport, and single-port laparoscopy technology. Although safe and efficacious, it is unclear how oncologic outcomes are impacted by surgical platform.

Objective: To identify differences in progression-free survival and overall survival in women undergoing minimally invasive surgery for endometrial cancer staging via either multiport, single-port, or robotic-assisted laparoscopy.

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Article Synopsis
  • - Women with advanced-stage low-grade serous ovarian carcinoma (LGSC) have limited responses to chemotherapy, making hormone therapy a promising treatment due to the overexpression of hormone receptors in these tumors.
  • - A study involving 27 patients indicated that those who underwent primary cytoreductive surgery (CRS) followed by hormone therapy had impressive outcomes, with 2-year progression-free and overall survival rates at 82.8% and 96.3%, respectively.
  • - The findings suggest that while surgery is crucial, hormone therapy could potentially eliminate the need for chemotherapy in advanced-stage LGSC patients, emphasizing the need for further Phase III trial investigations.
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Objectives: Participation in clinical and basic science research is emphasized in gynecologic oncology training. We sought to identify trends in adherence to expected research practices and reasons for non-adherence among gynecologic oncology fellows.

Methods: An anonymous 31-question online survey assessing academic behaviors, including IRB compliance, authorship assignment, data sharing, and potential barriers to non-adherence was distributed to all SGO gynecologic oncology fellow members in July 2016.

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Study Objective: To report surgical and pathologic outcomes after single-port laparoscopy (SPL) for adnexal masses in patients referred to a gynecologic oncology practice at a single academic institution.

Design: A retrospective analysis (Canadian Task Force Classification II.2).

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Background: Single-port laparoscopy has gained popularity within minimally invasive gynecologic surgery for its feasibility, cosmetic outcomes, and safety. However, within gynecologic oncology, there are limited data regarding short-term adverse outcomes and long-term hernia risk in patients undergoing single-port laparoscopic surgery.

Objective: The objective of the study was to describe short-term outcomes and hernia rates in patients after single-port laparoscopy in a gynecologic oncology practice.

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The prevalence of genital piercing among women is increasing. As the popularity increases, the number of complications from infection, injury, and retained jewelry is likely to rise. Techniques to remove embedded jewelry are not well described in the literature.

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Objectives: The aim of this study was to evaluate the antitumor activity of bevacizumab in low-grade serous ovarian carcinoma (LGSOC).

Methods: We retrospectively identified patients with LGSOC treated with bevacizumab.

Results: Twelve patients with LGSOC who received bevacizumab were identified.

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Objectives: The aims of the study were to examine barriers to cervical cancer screening among women who have experienced intimate partner violence (IPV) and accessed domestic violence shelters, to compare barriers among those up-to-date (UTD) and not UTD on screening, and to evaluate acceptability of human papillomavirus self-sampling.

Materials And Methods: This is a cross-sectional survey in which domestic violence shelters in Ohio were identified and women completed an anonymous survey assessing UTD screening status, barriers related to screening, history of IPV, intention to follow up on abnormal screening, and acceptability of self-sampling. Characteristics of UTD and not UTD women were compared using Mann-Whitney U tests.

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