Deep Learning-based Brain Age Prediction Using MRI to Identify Fetuses with Cerebral Ventriculomegaly.

Fetal ventriculomegaly (VM) and its severity and associated central nervous system (CNS) abnormalities are important indicators of high risk for impaired neurodevelopmental outcomes. Recently, a novel fetal brain age prediction method using a two-dimensional (2D) single-channel convolutional neural network (CNN) with multiplanar MRI sections showed the potential to detect fetuses with VM. This study examines the diagnostic performance of a deep learning-based fetal brain age prediction model to distinguish fetuses with VM ( = 317) from typically developing fetuses ( = 183), the severity of VM, and the presence of associated CNS abnormalities.