Safety and tolerability of antiretrovirals during pregnancy.

Combination antiretroviral therapy (CART) dramatically decreases mother-to-child HIV-1 transmission (MTCT), but maternal adverse events are not infrequent. A review of 117 locally followed pregnancies revealed 7 grade ≥ 3 AEs possibly related to antiretrovirals, including 2 hematologic, 3 hepatic, and 2 obstetric cholestasis cases. A fetal demise was attributed to obstetric cholestasis, but no maternal deaths occurred.

Novel approach to parental permission and child assent for research: improving comprehension.

Objective: The aim of this research was to test a multimedia permission/assent (P/A) process. The overall hypothesis was that children and their parents exposed to a multimedia P/A process would have better comprehension compared with those exposed to a text-based process.

Methods: Traditional and multimedia P/A processes were created by using an innovative learning-objective approach.

The diagnostic validity of hip provocation maneuvers to detect intra-articular hip pathology.

Objective: To determine which hip provocation maneuvers best predict the presence of an intra-articular hip pathology.

Design: Prospective diagnostic study.

Setting: Musculoskeletal clinic at a university-based multispecialty group practice.

Resistance to antiretrovirals in HIV-infected pregnant women.

Background: Antiretrovirals suppress HIV replication and prevent mother-to-child-transmission of HIV (PMTCT). Resistance to antiretrovirals may reduce the efficacy of PMTCT and/or complicate treatment of maternal or infant infection.

Objectives: To assess resistance to antiretrovirals during pregnancy.