Concerted adoption as an emerging strategy for digital transformation of healthcare-lessons from Australia, Canada, and England.

Objectives: With an increasing focus on the digitalization of health and care settings, there is significant scope to learn from international approaches to promote concerted adoption of electronic health records.

Materials And Methods: We review three large-scale initiatives from Australia, Canada, and England, and extract common lessons for future health and social care transformation strategy.

Results: We discuss how, despite differences in contexts, concerted adoption enables sharing of experience and learning to streamline the digital transformation of health and care.

A randomized, controlled crossover trial of ondansetron in patients with primary biliary cirrhosis and fatigue.

Fatigue is common in primary biliary cirrhosis (PBC). Altered central serotonergic neurotransmission may be involved in its pathogenesis. This multicenter, randomized, double-blind, placebo-controlled, crossover trial evaluated the efficacy of ondansetron, a selective 5-HT3 receptor subtype antagonist, for treating fatigue in PBC.

Hepatitis B virus replication in damaged endothelial tissues of patients with extrahepatic disease.

Hepatitis B virus (HBV) infection may be complicated by extrahepatic manifestations such as polyarteritis nodosa (PAN), glomerulonephritis, polymyositis, and dermatitis, but the etiology of these processes is not yet clear. HBV replication has been demonstrated in a variety of extrahepatic tissues and cell types, but the possible pathogenetic role of extrahepatic HBV replication has not been fully explored in patients with extrahepatic manifestations of HBV infection. In this case series, immunohistochemistry and in situ hybridization studies were performed on extrahepatic tissues from one HBsAg-positive patient with PAN and another HBsAg-positive patient with polymyositis, using HBsAg-seronegative control subjects with the same vasculitic disorders as controls.

Digital video for the documentation of colonoscopy.

Background: The aim of this study was to determine whether digital video is suitable for the documentation of colonoscopy. Standards are required for the visual documentation of endoscopic findings and to optimize image quality while limiting file size and bandwidth requirements.

Methods: Video recordings of colonoscopy procedures were encoded using a common video compression method at selected data rates and resolutions.