Publications by authors named "Jeremy Tetsuo Miyauchi"
Immunotherapies are becoming a promising strategy for malignant disease. Selectively directing host immune responses to target cancerous tissue is a milestone of human health care. The roles of the innate and adaptive immune systems in both cancer progression and elimination are now being realized.
View Article and Find Full Text PDFGliomas are primary malignancies of the brain. Tumors are staged based on malignancy, nuclear atypia, and infiltration of the surrounding brain parenchyma. Tumors are often diagnosed once patients become symptomatic, at which time the lesion is sizable.
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- Glioma-associated microglia and macrophages (GAM) are heavily influenced by tumor-derived cytokines, which diminish their antitumor properties and instead promote tumor growth and immune suppression.
- When mice lack the neuropilin-1 (Nrp1) receptor, they show reduced glioma size and increased antitumor responses due to a shift in GAM behavior.
- Manipulating Nrp1 in either peripheral macrophages or microglia can reprogram their functions, highlighting Nrp1's role in enhancing tumor blood supply and immune evasion in gliomas.