Publications by authors named "Jeremy T Lopez"
Cancer Discov
October 2017
Article Synopsis
- The study analyzed the enhancer landscape in 66 AML patients, discovering six new subgroups defined by their superenhancer maps and associated with unique leukemic characteristics.
- A notable finding was the identification of a strong superenhancer at the retinoic acid receptor alpha (RARA) gene locus, which links to higher sensitivity to the drug SY-1425 (tamibarotene) in cell lines and patient-derived models.
- The response to SY-1425 in RARA-high AML cells induces differentiation and reduces proliferation, suggesting potential targeted treatment strategies based on the superenhancer landscape for specific patient subgroups.
