Publications by authors named "Jeremy M Fung"
Article Synopsis
- * Researchers used advanced RNA-sequencing techniques on tumor samples taken from patients after four weeks of IDHi treatment to examine cellular changes.
- * Findings reveal that IDHi promotes differentiation of tumor cells toward a specific brain cell type (astrocytes), reduces stem-like cells, and highlights a mutation (NOTCH1) that may hinder this differentiation and affect treatment response.
Diverse genetic, epigenetic, and developmental programs drive glioblastoma, an incurable and poorly understood tumor, but their precise characterization remains challenging. Here, we use an integrative approach spanning single-cell RNA-sequencing of 28 tumors, bulk genetic and expression analysis of 401 specimens from the The Cancer Genome Atlas (TCGA), functional approaches, and single-cell lineage tracing to derive a unified model of cellular states and genetic diversity in glioblastoma. We find that malignant cells in glioblastoma exist in four main cellular states that recapitulate distinct neural cell types, are influenced by the tumor microenvironment, and exhibit plasticity.
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