Primary Cardiac Lymphoma in a Young and Immunocompetent Patient Diagnosed by Percutaneous Transvenous Biopsy.

Primary cardiac lymphoma is a rare cardiac neoplasm that is typically found in older, immunocompromised patients. In this case, we report an immunocompetent, 46-year-old female that presented with shortness of breath and chest discomfort. Diagnosis of primary cardiac lymphoma was confirmed by way of percutaneous transvenous biopsy under transesophageal echocardiography and cardiac fluoroscopy guidance.

Clinical Utility of Genomic Recurrence Risk Stratification in Early, Hormone-Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer: Real-World Experience.

Background: RNA-based genomic risk assessment estimates chemotherapy benefit in patients with hormone-receptor positive (HR+)/Human Epidermal Growth Factor 2-negative (ERBB2-) breast cancer (BC). It is virtually used in all patients with early HR+/ERBB2- BC regardless of clinical recurrence risk.

Patients And Methods: We conducted a retrospective chart review of adult patients with early-stage (T1-3; N0; M0) HR+/ERBB2- BC who underwent genomic testing using the Oncotype DX (Exact Sciences) 21-genes assay.

Liquid Biopsy-based Precision Therapy in Patients with Advanced Solid Tumors: A Real-world Experience from a Community-based Oncology Practice.

Background: Liquid biopsy testing offers a significant potential in selecting signal-matched therapies for advanced solid malignancies. The feasibility of liquid biopsy testing in a community-based oncology practice, and its actual impact on selecting signal-matched therapies, and subsequent survival effects have not previously been reported.

Patients And Methods: A retrospective chart review was conducted on adult patients with advanced solid cancer tested with a liquid-biopsy assay between December 2018 and 2019, in a community oncology practice.

SMARCB1/INI1-deficient tumors of adulthood.

The gene was first discovered in the mid-1990s, and since then it has been revealed that loss of function mutations in this gene result in aggressive rhabdoid tumors. Recently, the term "rhabdoid tumor" has become synonymous with decreased expression. When genetic aberrations in the gene occur, the result can cause complete loss of expression, decreased expression, and mosaic expression.

Case Report: Management of rectal squamous cell carcinoma - a treatment dilemma.

Primary rectal squamous cell carcinoma is rare compared to adenocarcinoma, which is the predominant histologic type most commonly discovered at the time of colorectal carcinoma diagnosis. Due to the infrequent nature of this malignancy, data on tumor pathogenesis and risk factors remains sparse. Moreover, no standardized therapeutic regimen exists.

A Case of Acute Heart Failure Following Immunotherapy for Metastatic Lung Cancer.

Inhibitors of cytotoxic T-lymphocyte-associated antigen-4, programmed cell death protein-1, and programmed death-ligand 1 have been shown to produce significant antitumor activity in multiple malignancies, and have become essential oncology standard-of-care therapies. Despite their success, the checkpoint inhibitors' ability to amplify the immune system response against tumor cells has been associated with a unique panel of side effects known as immune-related adverse events. The involvement of the myocardium has been reported previously, but it's remarkably uncommon.

SMARCB1/INI1-Deficient Extrarenal Rhabdoid Tumor: A Case Report of a Rare and Aggressive Soft Tissue Sarcoma.

Malignant SMARCB1/INI1-deficient extrarenal rhabdoid tumors are aggressive tumors that are extremely rare in adults. A 56-year-old male presented with the chief complaints of unilateral lower abdominal and pelvic pain. He underwent urgent surgical intervention and mass resection with tissue sampling.

Imatinib Dosing in Gastrointestinal Stromal Tumors (GISTs): When, How Much, and How Long?

Imatinib therapy has revolutionized the treatment of patients with gastrointestinal stromal tumors (GISTs). Compared with older therapy, imatinib significantly improves outcomes in patients with metastatic disease and those with locally advanced tumors, raising progression-free and overall survival. Recent studies have evaluated variables such as timing of treatment, total dosing, and duration of therapy.

Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients.

Aim: To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following esophagectomy.

Methods: We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and Clinics between 2000 and 2010. Data analyzed consisted of demographic and clinical variables.

Acquired factor VIII inhibitors: case reports of paclitaxel and penicillin-induced entities.

Acquired hemophilia A is an uncommon but potentially life-threatening clinical entity mediated by specific autoantibodies direct against coagulation factor VIII. It may be associated with a number of conditions such as solid malignancies, autoimmune diseases, lymphoproliferative disorders, and drugs. Early recognition of this entity is necessary to avoid a delay in treatment, which might lead to serious complications including severe bleeding and death.