Brain diffusion tensor imaging in dogs with degenerative myelopathy.

Background: Degenerative myelopathy (DM) in dogs shares similarities with superoxide dismutase 1-associated human amyotrophic lateral sclerosis (ALS). Brain microstructural lesions are quantified using diffusion tensor imaging (DTI) in ALS patients.

Objective: Characterize brain neurodegenerative changes in DM-affected dogs using DTI.